Zwart, Mark Peter; Tromas ., Nicolas; Elena Fito, Santiago Fco(Public Library of Science, 2013-05)
The cellular multiplicity of infection (MOI) is a key parameter for describing the interactions between virions and cells, predicting the dynamics of mixed-genotype infections, and understanding virus evolution. Two recent ...
Ambros Palaguerri, Silvia; Martinez, F.; Ivars, P.; Hernandez Fort, Carmen; De la Iglesia Jordán, Francisca; Elena Fito, Santiago Fco.(Springer-Verlag, 2017)
[EN] Tomato is known to be a natural and experimental reservoir host for many plant viruses. In the last few years a new tobamovirus species, Tomato mottle mosaic virus (ToMMV), has been described infecting tomato and ...
Cuevas Torrijos, Jose Manuel; Delaunay, Agnes; Rupar, Matevz; Jacquot, Emmanuel; Elena Fito, Santiago Fco(Microbiology Society, 2012-11)
Potato virus Y (PVY) is an important plant pathogen with a wide host range that includes, among others, potato, tobacco, tomato and pepper. The coat protein (CP) of PVY has been commonly used in phylogenetic studies for ...
Minicka, J; Rymelska, N; Elena Fito, Santiago Fco; Czerwoniec, A; Hasiów-Jaroszewska, B(Wiley, 2015-05)
In this study the effect of host changes and multiple passages on Pepino mosaic virus (PepMV) evolution was analysed. A population of a mild isolate of PepMV was used to generate five independent evolution lineages on three ...
Hasiów-Jaroszewska, Beata; Fares Riaño, Mario Ali; Elena Fito, Santiago Fco(Springer Verlag (Germany), 2014-01)
[EN] Our knowledge on the mode of evolution of the multifunctional viral proteins remains incomplete. To tackle this problem, here, we have investigated the evolutionary dynamics of the potyvirus multifunctional protein ...
Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2012-05)
[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and the severity ...
Sardanyes, J.; Arderiu, A.; ELENA FITO, SANTIAGO FCO; Alarcon, T.(The Royal Society, 2018-05)
[EN] Evolutionary and dynamical investigations into real viral populations indicate that RNA replication can range between the two extremes represented by so-called 'stamping machine replication' (SMR) and 'geometric ...
Chao, Lin; ELENA FITO, SANTIAGO FCO(The Royal Society, 2017-05-10)
[EN] The existence of cooperation, or the production of public goods, is an evolutionary
problem. Cooperation is not favoured because the Prisoner s
Dilemma (PD) game drives cooperators to extinction. We have re-analysed
this ...
Zwart, Mark Peter; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(Public Library of Science, 2011)
[EN] Effective population size (N-e) determines the strength of genetic drift and the frequency of co-infection by multiple genotypes, making it a key factor in viral evolution. Experimental estimates of N-e for different ...
Rodrigo Tarrega, Guillermo; Zwart, Mark Peter; Elena Fito, Santiago Fco(Royal Society Publishing, 2014-09-06)
The cornerstone of today's plant virology consists of deciphering the molecular and mechanistic basis of host-pathogen interactions. Among these interactions, the onset of systemic infection is a fundamental variable in ...
Rodrigo Tarrega, Guillermo; Carrera, Javier; Jaramillo, Alfonso; Elena Fito, Santiago Fco(Royal Society, The, 2011-02-06)
[EN] The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action triggered by the intracellular ...
Gomez, P.; Sempere, R.N.; Aranda, M.A.; Elena Fito, Santiago Fco(Springer Verlag (Germany), 2012-11)
[EN] Pepino mosaic virus (PepMV) is an emerging pathogen that causes severe economic losses in tomato crops in the Northern hemisphere. After its first identification, the new viral strain PepMV-CH2 has been isolated in ...
Cuevas Torrijos, Jose Manuel; Delaunay, Agnes; Visser, Johan C.; Bellstedt, Dirk U.; Jacquot, Emmanuel; Elena Fito, Santiago Fco(Public Library of Science, 2012-05)
Potato virus Y (PVY) is an important plant pathogen, whose host range includes economically important crops such as potato, tobacco, tomato, and pepper. PVY presents three main strains (PVYO, PVYN and PVYC) and several ...
Elena Fito, Santiago Fco; Lalic, Jasna(Wiley, 2013-12)
[EN] Forecasting plant virus emergence depends on identifying the factors that determine the distribution of genetic variants within the primary host as well as across potential new hosts. It is crucial to determine: (i) ...
González, Rubén; Butkovic, Anamarija; Escaray, Francisco J.; Martínez-Latorre, Javier; Melero, Izan; Pérez-Parets, Enric; Gómez-Cadenas, Aurelio; Carrasco, Pedro; Elena, Santiago F.(Proceedings of the National Academy of Sciences, 2021-02-09)
[EN] Environmental conditions are an important factor driving pathogens' evolution. Here, we explore the effects of drought stress in plant virus evolution. We evolved turnip mosaic potyvirus in well-watered and drought ...
Castaño Sansano, Mª Aurora; Ruiz Garcia, Maria Leticia; Elena Fito, Santiago Fco; Hernandez Fort, Carmen(Elsevier, 2011-01)
[EN] The genomic structure of Pelargonium line pattern virus (PLPV), a tentative member of a proposed new genus within the family Tombusviridae, has been recently determined. However, little is known about the genetic ...
Willemsen, Anouk; Zwart, Mark Peter; Higueras, Pablo; Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2016-09)
One of the striking features of many eukaryotes is the apparent amount of redundancy in coding and non-coding elements of their genomes. Despite the possible evolutionary advantages, there are fewer examples of redundant ...
Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco(Public Library of Science, 2011)
[EN] Empirical observations and theoretical studies suggest that viruses may use different replication strategies to amplify their genomes, which impact the dynamics of mutation accumulation in viral populations and ...
Majer, Eszter; Salvador, Zaira; Zwart, Mark Peter; Willemsen, Anouk; Elena Fito, Santiago Fco; Daros Arnau, Jose Antonio(American Society for Microbiology, 2014-04)
[EN] Potyviruses express most of their proteins from a long open reading frame that is translated into a large polyprotein processed by three viral proteases. To understand the constraints on potyvirus genome organization, ...
[EN] In general terms, robustness is the capacity of biological systems to function in spite of genetic or environmental perturbations. The small and compacted genomes and high mutation rates of RNA viruses, as well as the ...