Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse
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https://riunet.upv.es/handle/10251/47184
Cita bibliográfica
Vendrell Criado, V.; Rodríguez Muñiz, GM.; Cuquerella Alabort, MC.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2013). Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse. Angewandte Chemie International Edition. 52(25):6476-6479. doi:10.1002/anie.201302176
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A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage.
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Angewandte Chemie International Edition issn: 1433-7851