MicroRNA precursors are not structurally robust but plastic

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dc.contributor.authorRodrigo Tarrega, Guillermoes_ES
dc.contributor.authorElena Fito, Santiago Fcoes_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderEuropean Molecular Biology Organizationes_ES
dc.date.accessioned2016-07-22T09:13:18Z
dc.date.available2016-07-22T09:13:18Z
dc.date.issued2013
dc.description.abstractRobustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question whether microRNA precursors (pre-miRNAs) are actually structurally robust, as previously suggested. We found that natural pre-miRNAs are not more robust than expected under an appropriate null model. On the contrary, we found that eukaryotic pre-miRNAs show a significant enrichment in conformational flexibility at the thermal equilibrium of the molecule, that is, in their plasticity. Our results further support the selection for functional diversification and evolvability in sncRNAs.es_ES
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationRodrigo Tarrega, G.; Elena Fito, SF. (2013). MicroRNA precursors are not structurally robust but plastic. Genome Biology and Evolution. 5(1):181-186. https://doi.org/10.1093/gbe/evs132es_ES
dc.description.issue1es_ES
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dc.description.sponsorshipThe authors thank R. B. R. Azevedo for useful comments. This work was supported by an EMBO long-term fellowship co-funded by Marie Curie actions (ALTF-1177-2011) to G. R. and by grant BFU2012-30805 from the Spanish Secretaria de Estado de Investigacion, Desarrollo e Innovacion, to S.F.E.en_EN
dc.description.upvformatpfin186es_ES
dc.description.upvformatpinicio181es_ES
dc.description.volume5es_ES
dc.identifier.doi10.1093/gbe/evs132
dc.identifier.issn1759-6653
dc.identifier.pmcidPMC3595027en_EN
dc.identifier.pmid23275486en_EN
dc.identifier.urihttps://riunet.upv.es/handle/10251/68012
dc.languageEspañoles_ES
dc.publisherOxford University Press (OUP)es_ES
dc.relation.ispartofGenome Biology and Evolutiones_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/Marie Skłodowska-Curie Actions/ALTF-1177-2011/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2012-30805/ES/EVOLUTIONARY SYSTEMS VIROLOGY: EPISTASIS AND THE RUGGEDNESS OF ADAPTIVE LANDSCAPES, MUTATIONS IN REGULATORY SEQUENCES, AND THE HOST DETERMINANTS OF VIRAL FITNESS/es_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1093/gbe/evs132es_ES
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dc.relation.senia233407es_ES
dc.rightsReserva de todos los derechoses_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectConformational flexibilityes_ES
dc.subjectEvolvabilityes_ES
dc.subjectNoncoding RNAes_ES
dc.subjectSecondary structurees_ES
dc.subjectThermodynamicses_ES
dc.titleMicroRNA precursors are not structurally robust but plastices_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
upv.uuid5af40fb4-886f-426c-9f97-d84788229130es_ES

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