Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube

dc.contributor.affiliationInstituto de Instrumentación para Imagen Molecular
dc.contributor.authorGonzález Martínez, Antonio Javier
dc.contributor.authorBerr, Stuart S.es_ES
dc.contributor.authorCañizares-Ledo, Gabrieles_ES
dc.contributor.authorGonzalez-Montoro, Andreaes_ES
dc.contributor.authorOrero Palomares, Abeles_ES
dc.contributor.authorCorrecher Salvador, Carloses_ES
dc.contributor.authorRezaei, Ahmadrezaes_ES
dc.contributor.authorNuyts, Johanes_ES
dc.contributor.authorF Sánchez
dc.contributor.authorMajewski, Stanes_ES
dc.contributor.authorBenlloch Baviera, Jose María
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.contributor.funderResearch Foundation Flanders
dc.contributor.funderUniversity of Virginia
dc.date.accessioned2020-03-24T06:14:11Z
dc.date.available2020-03-24T06:14:11Z
dc.date.issued2018-11-28es_ES
dc.description.abstract[EN] There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationGonzález Martínez, AJ.; Berr, SS.; Cañizares-Ledo, G.; Gonzalez-Montoro, A.; Orero Palomares, A.; Correcher Salvador, C.; Rezaei, A.... (2018). Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube. Frontiers in Medicine. 5:1-8. https://doi.org/10.3389/fmed.2018.00328es_ES
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dc.description.sponsorshipThis project was funded in part by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 695536). It has also been supported by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R and through PROSPET (DTS15/00152) funded by the Ministerio de Economia y Competitividad. AR is a postdoctoral fellow of the FWO (project 12T7118N). The University of Virginia School of Medicine has provided seed funding for this project.es_ES
dc.description.upvformatpfin8es_ES
dc.description.upvformatpinicio1es_ES
dc.description.volume5es_ES
dc.identifier.doi10.3389/fmed.2018.00328es_ES
dc.identifier.eissn2296-858Xes_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/139238
dc.languageIngléses_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.ispartofFrontiers in Medicinees_ES
dc.relation.pasarelaS\406064es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//TEC2016-79884-C2-1-R/ES/DESARROLLO DEL HARDWARE PARA SISTEMA DE DIAGNOSTICO POR IMAGEN MOLECULAR PARA CORAZON EN CONDICIONES DE ESTRES/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DTS15%2F00152/ES/Desarrollo de un detector PET para guiar la biopsia, el tratamiento y el seguimiento del cáncer de próstata (PROSPECT)/
dc.relation.projectIDinfo:eu-repo/grantAgreement/FWO//12T7118N/
dc.relation.publisherversionhttps://doi.org/10.3389/fmed.2018.00328es_ES
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dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectPositron emission tomographyes_ES
dc.subjectHybrid PET-MRes_ES
dc.subjectMonolithic crystales_ES
dc.subjectSiPMes_ES
dc.subjectPreclinical imaginges_ES
dc.titleFeasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tubees_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
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