DNA methylation in plants: mechanisms and tools for targeted manipulation.

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dc.contributor.authorGallego Bartolomé, Javier
dc.contributor.funderEuropean Commissiones_ES
dc.date.accessioned2023-12-21T19:01:58Z
dc.date.available2023-12-21T19:01:58Z
dc.date.issued2020-07es_ES
dc.description.abstract[EN] DNA methylation is an epigenetic mark that regulates multiple processes, such as gene expression and genome stability. Mutants and pharmacological treatments have been instrumental in the study of this mark in plants, although their genome-wide effect complicates the direct association between changes in methylation and a particular phenotype. A variety of tools that allow locus-specific manipulation of DNA methylation can be used to assess its direct role in specific processes, as well as to create novel epialleles. Recently, new tools that recruit the methylation machinery directly to target loci through programmable DNA-binding proteins have expanded the tool kit available to researchers. This review provides an overview of DNA methylation in plants and discusses the tools that have recently been developed for its manipulation.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationGallego Bartolomé, J. (2020). DNA methylation in plants: mechanisms and tools for targeted manipulation. New Phytologist. 227(1):38-44. https://doi.org/10.1111/nph.16529es_ES
dc.description.issue1es_ES
dc.description.sponsorshipI would like to thank Drs Steve Jacobsen, Jake Harris, German Martinez, Maria A. Nohales, Miguel Blazquez and David Alabadi, as well as three anonymous reviewers for their critical reading of this manuscript and insightful comments. I would also like to apologize to colleagues whose work is not included in this manuscript due to space limitations. JG-B is funded by a Marie Curie Reintegration grant (MSCA-IF EU project 835599).es_ES
dc.description.upvformatpfin44es_ES
dc.description.upvformatpinicio38es_ES
dc.description.volume227es_ES
dc.identifier.doi10.1111/nph.16529es_ES
dc.identifier.issn0028-646Xes_ES
dc.identifier.pmid32159848es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/201043
dc.languageIngléses_ES
dc.publisherBlackwell Publishinges_ES
dc.relation.ispartofNew Phytologistes_ES
dc.relation.pasarelaS\432875es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/835599/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.1111/nph.16529es_ES
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dc.rightsReserva de todos los derechoses_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectArtificial zinc finger proteinses_ES
dc.subjectCRISPR SunTages_ES
dc.subjectDNA methylationes_ES
dc.subjectRNA-directed DNA methylationes_ES
dc.subjectTranscriptional gene silencinges_ES
dc.titleDNA methylation in plants: mechanisms and tools for targeted manipulation.es_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
person.identifier4579
relation.isAuthorOfPublication2904f4f9-ea64-4c41-8503-bbd8fa79f3aa
relation.isAuthorOfPublication.latestForDiscovery2904f4f9-ea64-4c41-8503-bbd8fa79f3aa
upv.uuid74fc411e-770c-4c23-bdd9-396a32a4b4d1es_ES

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