Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization

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dc.contributor.affiliationInstituto Universitario Mixto de Biología Molecular y Celular de Plantas
dc.contributor.affiliationCentro de Biomateriales e Ingeniería Tisular
dc.contributor.authorRico Tortosa, Patricia María
dc.contributor.authorRodrigo Navarro, Aleixandrees_ES
dc.contributor.authorLa Peña Del Rivero, Marcos De
dc.contributor.authorMoulisova, Vladimiraes_ES
dc.contributor.authorCostell, Mercedeses_ES
dc.contributor.authorSalmerón Sánchez, Manueles_ES
dc.contributor.funderUK Research and Innovationes_ES
dc.contributor.funderMinisterio de Ciencia e Innovaciónes_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.contributor.funderEngineering and Physical Sciences Research Council, Reino Unidoes_ES
dc.contributor.funderCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicinaes_ES
dc.date.accessioned2020-06-13T03:32:50Z
dc.date.available2020-06-13T03:32:50Z
dc.date.issued2018-10-30es_ES
dc.description.abstract[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and show that simultaneous stimulation of NaBC1 and vascular growth factor receptors (VEGFR) promote angiogenesis in vitro and in vivo with ultra-low concentrations of VEGF. We show Human Umbilical Vein Endothelial Cells (HUVEC) organization into tubular structures indicative of vascularization potential. Enhanced cell sprouting was found only in the presence of VEGF and boron, effect abrogated after blocking NaBC1. We demonstrate that stimulated NaBC1 promotes angiogenesis via PI3k-independent pathways and that ¿5ß1/¿vß3-integrin binding is not essential to enhanced HUVEC organization. We describe a novel vascularization mechanism that involves the crosstalk and colocalization between NaBC1/VEGFR receptors. This has important translational consequences: just by administering boron, taking advantage of endogenous VEGF, in vivo vascularization is shown in a chorioallantoic membrane assay.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationRico Tortosa, PM.; Rodrigo Navarro, A.; La Peña Del Rivero, MD.; Moulisova, V.; Costell, M.; Salmerón Sánchez, M. (2018). Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization. Advanced Biosystems. 3(1):1-12. https://doi.org/10.1002/adbi.201800220es_ES
dc.description.issue1es_ES
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dc.description.sponsorshipP.R. acknowledges support from the Ministerio de Economia, Industria y Competitividad, Gobierno de Espana (MINECO) (MAT2015-69315-C3-1-R), and European Regional Development Fund (FEDER). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. M. S. S. acknowledges support from the European Research Council (ERC-HealInSynergy 306990) and the UK Engineering and Physical Sciences Research Council (EPSRC-EP/P001114/1). The authors are very grateful to Productos Florida farm for kindly providing chick embryos for CAM assay.es_ES
dc.description.upvformatpfin12es_ES
dc.description.upvformatpinicio1es_ES
dc.description.volume3es_ES
dc.identifier.doi10.1002/adbi.201800220es_ES
dc.identifier.eissn2366-7478es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/146286
dc.languageIngléses_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relation.ispartofAdvanced Biosystemses_ES
dc.relation.pasarelaS\379964es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/306990/EU/Material-driven Fibronectin Fibrillogenesis to Engineer Synergistic Growth Factor Microenvironments/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/UKRI//EP%2FP001114%2F1/GB/Engineering growth factor microenvironments - a new therapeutic paradigm for regenerative medicine/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//MAT2015-69315-C3-1-R/ES/SOPORTES CELULARES BIODEGRADABLES CARGADOS CON IONES BIOACTIVOS PARA REGENERACION MUSCULAR/es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/adbi.201800220es_ES
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dc.rightsReserva de todos los derechoses_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectNaBC1es_ES
dc.subjectBoron iones_ES
dc.subjectVEGFes_ES
dc.subjectVascularizationes_ES
dc.subjectFibronectines_ES
dc.subjectIntegrinses_ES
dc.subject.classificationFISICA APLICADAes_ES
dc.titleSimultaneous boron ion-channel/growth factor receptor activation for enhanced vascularizationes_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
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