Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates

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dc.contributor.affiliationInstituto Universitario Mixto de Tecnología Química
dc.contributor.authorFrancés-Monerris, Antonioes_ES
dc.contributor.authorLineros-Rosa, Mauricioes_ES
dc.contributor.authorMiranda Alonso, Miguel Ángeles_ES
dc.contributor.authorLhiaubet, Virginie Lyria
dc.contributor.authorMonari, Antonioes_ES
dc.contributor.funderEuropean Social Fundes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderUniversité de Lorrainees_ES
dc.contributor.funderUniversitat Politècnica de Valènciaes_ES
dc.contributor.funderCentre National de la Recherche Scientifique, Franciaes_ES
dc.contributor.funderAgencia Estatal de Investigaciónes_ES
dc.date.accessioned2021-04-21T03:31:44Z
dc.date.available2021-04-21T03:31:44Z
dc.date.issued2020-04-25es_ES
dc.description.abstract[EN] The propensity of 5-formyluracil and 5-formylcytosine, i.e. oxidative lesions and epigenetic intermediates, in acting as intrinsic DNA photosensitizers is unraveled by using a combination of molecular modeling, simulation and spectroscopy. Exploration of potential energy surfaces and non-adiabatic dynamics confirm a higher intersystem crossing rate for 5-formyluracil, whereas the kinetic models evidence different equilibria in the excited states for both compounds.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationFrancés-Monerris, A.; Lineros-Rosa, M.; Miranda Alonso, MÁ.; Lhiaubet, VL.; Monari, A. (2020). Photoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates. Chemical Communications. 56(32):4404-4407. https://doi.org/10.1039/d0cc01132kes_ES
dc.description.issue32es_ES
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dc.description.sponsorshipSupport from the Universite de Lorraine, CNRS and Spanish Government (PGC2018-096684-B-I00) is kindly acknowledged. A. F.-M. is grateful to Generalitat Valenciana (CTQ2017-87054-C2-2-P) and the European Social Fund for a postdoctoral contract (APOSTD/2019/149), M. L.-R. acknowledges the Universitat Politecnica de Valencia for the FPI grant. Calculations have been performed on the local LPCT computer center and on the Explor regional center in the framework of the project "Dancing under the light''.es_ES
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dc.identifier.doi10.1039/d0cc01132kes_ES
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dc.identifier.urihttps://riunet.upv.es/handle/10251/165411
dc.languageIngléses_ES
dc.publisherThe Royal Society of Chemistryes_ES
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dc.relation.publisherversionhttps://doi.org/10.1039/d0cc01132kes_ES
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dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subject.classificationQUIMICA ORGANICAes_ES
dc.titlePhotoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediateses_ES
dc.typeArtículoes_ES
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