Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

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dc.contributor.affiliationInstituto Universitario Mixto de Tecnología Química
dc.contributor.authorZaragoza, Ramon J.es_ES
dc.contributor.authorGonzález-Cardenete, Miguel A
dc.contributor.funderUniversitat Politècnica de Valènciaes_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicases_ES
dc.date.accessioned2021-11-05T12:27:21Z
dc.date.available2021-11-05T12:27:21Z
dc.date.issued2020-04-15es_ES
dc.description.abstract[EN] The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed. This key aldol reaction was very sensitive to steric hindrance. This fact has been studied by deuterium exchange experiments and DFT methods. Optimization of this reaction led to the synthesis of anti-inflammatory bodinieric acids A and B, starting from abietic aciden_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationZaragoza, RJ.; González-Cardenete, MA. (2020). Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction. RSC Advances. 10(25):15015-15022. https://doi.org/10.1039/d0ra02711aes_ES
dc.description.issue25es_ES
dc.description.sponsorshipFinancial support has been provided by the Spanish Government [CSIC (201680I008)] and the Universidad de Valencia, Spaines_ES
dc.description.upvformatpfin15022es_ES
dc.description.upvformatpinicio15015es_ES
dc.description.volume10es_ES
dc.identifier.doi10.1039/d0ra02711aes_ES
dc.identifier.eissn2046-2069es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/176087
dc.languageIngléses_ES
dc.publisherThe Royal Society of Chemistryes_ES
dc.relation.ispartofRSC Advanceses_ES
dc.relation.pasarelaS\414990es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/CSIC//201680I008/ES/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/UPV//AD1902/ES/DISEÑO, DESARROLO Y CARACTERIZACION DE ANTIVIRALES FLUORESCENTES DE PRODUCCION SOSTENIBLE PARA ENFERMEDADES TROPICALES Y CO-INFECCIONES OPORTUNISTAS EN VIH DE ALTA PREVALENCIA EN AMERICA LATINA/es_ES
dc.relation.publisherversionhttps://doi.org/10.1039/d0ra02711aes_ES
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dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.titleSynthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reactiones_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
person.identifier565934
person.identifier.orcid0000-0002-8762-0426
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