Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass

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dc.contributor.authorSempere, Lauraes_ES
dc.contributor.authorFernández, Carloses_ES
dc.contributor.authorIbañez, Soledades_ES
dc.contributor.authorMarín, Conradoes_ES
dc.contributor.authorMolés, Gregorioes_ES
dc.contributor.authorPérez-Sánchez, Jaumees_ES
dc.contributor.authorMartínez, Paulinoes_ES
dc.contributor.authorViñas, Anaes_ES
dc.contributor.authorFelip, Aliciaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderAgencia Estatal de Investigaciónes_ES
dc.contributor.funderEuropean Regional Development Fundes_ES
dc.contributor.funderMinisterio de Ciencia e Innovaciónes_ES
dc.date.accessioned2026-05-14T13:15:40Z
dc.date.available2026-05-14T13:15:40Z
dc.date.issued2025-01-30es_ES
dc.description.abstract[EN] It is known that the insulin-like growth factor (Igf) system is involved in gonadal development and, in turn, reproduction in vertebrates. In this study, the circulating levels of Igf-1 and follicle-stimulating hormone (Fsh) were assessed as physiological signals related to gonadal maturation stage in juvenile male European sea bass at 1 year of age. The seasonal profiles of Igf-1 and Fsh were analyzed in non-precocious (NP) and precocious (PR) fish during the early onset of puberty. Subsequently, gonadal expression patterns of the three igf genes and their two receptors, igf-1r and igf-2r, were studied during their first year of life. The analysis was continued to evaluate the mRNA expression profiles of three genes (sox17, scf, nf2) mediating spermatogenesis progression. Collectively, these results demonstrated that PR males have higher circulating levels of Igf-1 as compared to NP fish before and during the putative gonadal development period (PGD). Plasma Fsh levels were significantly higher in PR males as compared to NP fish before the start of the PGD period, although this was followed by a decrease in Fsh levels and a subsequent recovery, coinciding with the reproductive season (February). Results showed that the total variance associated with the appearance of precocity may be explained by the contribution of factors such as body size and plasma levels of Igf-1, Fsh and sex steroids in male sea bass. Expression of igfs was high during stage I, and this was significantly correlated with the expression of genes related to cell cycle progression, including sox17, scf and nf2. Finally, the decreased expression of all these gonadal factors in precocious animals suggests their potential involvement in regulating the proliferative growth of spermatogonia and supporting cells during the early stages of spermatogenesis, thus evoking the onset of puberty in male sea bass.es_ES
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationSempere, L.; Fernández, C.; Ibañez, S.; Marín, C.; Molés, G.; Pérez-Sánchez, J.; Martínez, P.... (2025). Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass. Aquaculture. 595. https://doi.org/10.1016/j.aquaculture.2024.741647es_ES
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dc.description.sponsorshipThis research was financially supported by Spanish Grants AGL2016-75400-R (PUBERTRAIT) and PID2019-109548RB-I00 (REPROBOOST), funded by MCIN/AEI/10.13039/501100011033 and ERDF, A way of making Europe, and by a grant from the Valencian Regional Government CIAICO/2022/002. L.S. was supported by an FPI fellowship (PRE2020-094920) from MICIN.es_ES
dc.description.volume595es_ES
dc.identifier.doi10.1016/j.aquaculture.2024.741647es_ES
dc.identifier.issn0044-8486es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/235154
dc.languageIngléses_ES
dc.publisherElsevieres_ES
dc.relation.ispartofAquaculturees_ES
dc.relation.pasarelaS\582954es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109548RB-I00/ES/PROPUESTAS PARA IMPULSAR EL RENDIMIENTO REPRODUCTIVO EN LA LUBINA: INTERACCION CRECIMIENTO-MADURACION Y MEJORA DE LA CALIDAD DE LOS GAMETOS A TRAVES DE LA DIETA/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/GVA//CIAICO%2F2022%2F002/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PRE2020-094920/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//AGL2016-75400-R/es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.aquaculture.2024.741647es_ES
dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectSpermatogenesises_ES
dc.subjectIgf-systemes_ES
dc.subjectProliferation-related geneses_ES
dc.subjectTeleostes_ES
dc.subjectAquaculturees_ES
dc.titleParticipation of the insulin-like growth factor system in the early maturity in juvenile male European sea basses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
upv.uuid98fd780d-ee51-40ed-a000-5b2c843da87des_ES

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