Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs

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dc.contributor.authorMartin-Biosca, Y.es_ES
dc.contributor.authorTorres-Cartas, Sagrarioes_ES
dc.contributor.authorVillanueva-Camanas, R. M.es_ES
dc.contributor.authorSagrado, S.es_ES
dc.contributor.authorMedina-Hernandez, M. J.es_ES
dc.contributor.funderMinisterio de Educación y Cienciaes_ES
dc.date.accessioned2015-09-17T14:12:27Z
dc.date.available2015-09-17T14:12:27Z
dc.date.issued2009-01-26
dc.description.abstract[EN] Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting the partition coefficients from blood to lung, blood to liver. blood to fat and blood to skin is demonstrated. PLS2 and multiple linear regression (MLR) models based on BMC retention data are proposed and compared with other ones reported in bibliography. The proposed models present better or similar descriptive and predictive capability. (C) 2008 Elsevier B.V. All rights reserved.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationMartin-Biosca, Y.; Torres-Cartas, S.; Villanueva-Camanas, RM.; Sagrado, S.; Medina-Hernandez, MJ. (2009). Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs. Analytica Chimica Acta. 632(2):296-303. https://doi.org/10.1016/j.aca.2008.11.004es_ES
dc.description.issue2es_ES
dc.description.sponsorshipThe authors acknowledge the Spanish Ministry of Science and Technology (MCYT) and the European Regional Development Fund (ERDF) for the financial support (Project SA2005-01435).
dc.description.upvformatpfin303es_ES
dc.description.upvformatpinicio296es_ES
dc.description.volume632es_ES
dc.identifier.doi10.1016/j.aca.2008.11.004
dc.identifier.issn0003-2670
dc.identifier.pmid19110108
dc.identifier.urihttps://riunet.upv.es/handle/10251/54766
dc.languageIngléses_ES
dc.publisherElsevier Massones_ES
dc.relation.ispartofAnalytica Chimica Actaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MEC//SAF2005-01435/es_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.aca.2008.11.004es_ES
dc.relation.senia34314
dc.rightsReserva de todos los derechoses_ES
dc.rights.accessRightsCerradoes_ES
dc.subjectPartition coefficientses_ES
dc.subjectBlood to lunges_ES
dc.subjectBlood to fates_ES
dc.subjectBlood to liveres_ES
dc.subjectBlood to skines_ES
dc.subjectBiopartitioning micellar chromatographyes_ES
dc.subject.classificationQUIMICA ANALITICAes_ES
dc.titleBiopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
upv.uuidabb178f3-601d-409c-82b8-a7fa5dedd165es_ES

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