A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes

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dc.contributor.authorGrillo-Risco, Rubénes_ES
dc.contributor.authorHidalgo, Marta R.es_ES
dc.contributor.authorMartinez-Rojas, Beatrizes_ES
dc.contributor.authorMoreno-Manzano, Victoriaes_ES
dc.contributor.authorGarcía-García, Franciscoes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderAgencia Estatal de Investigaciónes_ES
dc.contributor.funderEuropean Regional Development Fundes_ES
dc.date.accessioned2026-05-08T11:58:39Z
dc.date.available2026-05-08T11:58:39Z
dc.date.issued2025-02-04es_ES
dc.description.abstract[EN] Spinal cord injury (SCI) is a devastating condition that leads to motor, sensory, and autonomic dysfunction. Current therapeutic options remain limited, emphasizing the need for a comprehensive understanding of the underlying SCI-associated molecular mechanisms. This study characterized distinct SCI phases and severities at the gene and functional levels, focusing on biomarker gene identification. Our approach involved a systematic review, individual transcriptomic analysis, gene meta-analysis, and functional characterization. We compiled a total of fourteen studies with 273 samples, leading to the identification of severity- and phase-specific biomarker genes that allow the precise classification of transcriptomic profiles. We investigated the potential transferability of severity-specific biomarkers and identified a twelve-gene signature that predicted injury prognosis from human blood samples. We also report the development of MetaSCI-app - an interactive web application designed for researchers - that allows the exploration and visualization of all generated results (https://metasci-cbl.shinyapps.io/metaSCI). Overall, we present a transcriptomic reference and provide a comprehensive framework for assessing SCI considering severity and time perspectives, all integrated into a user-friendly tool.es_ES
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationGrillo-Risco, R.; Hidalgo, MR.; Martinez-Rojas, B.; Moreno-Manzano, V.; García-García, F. (2025). A comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker genes. Journal of Translational Medicine. 23(160). https://doi.org/10.1186/s12967-024-06009-6es_ES
dc.description.issue160es_ES
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dc.description.sponsorshipThis research was supported and partially funded by the Institute of Health Carlos III (project IMPaCT-Data, IMP/00019), co-funded by ERDF, A way to make Europe ; PID2021-124430OA-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, UE; and CIAICO/2023/149 funded by the Consellería de Educación, Cultura, Universidades y Empleo de la Generalitat Valenciana.es_ES
dc.description.volume23es_ES
dc.identifier.doi10.1186/s12967-024-06009-6es_ES
dc.identifier.eissn1479-5876es_ES
dc.identifier.pmcidPMC11796280
dc.identifier.pmid39905473
dc.identifier.urihttps://riunet.upv.es/handle/10251/234993
dc.languageIngléses_ES
dc.publisherSpringer (Biomed Central Ltd.)es_ES
dc.relation.ispartofJournal of Translational Medicinees_ES
dc.relation.pasarelaS\538315es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124430OA-I00/ES/ESTUDIO DE LAS DIFERENCIAS DE SEXO EN ENFERMEDADES NEURODEGENERATIVAS CON ABORDAJES INTEGRATIVOS DE DATOS OMICOS E IMAGEN BIOMEDICA/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/GVA//CIAICO%2F2023%2F149/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//IMP%2F00019/es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/s12967-024-06009-6es_ES
dc.rightsReconocimiento - No comercial - Sin obra derivada (by-nc-nd)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectSpinal cord injuryes_ES
dc.subjectTranscriptomicses_ES
dc.subjectMeta-analysises_ES
dc.subjectBiomarkerses_ES
dc.subjectFunctional profilinges_ES
dc.subjectTranslationales_ES
dc.subjectPrognosises_ES
dc.titleA comprehensive transcriptional reference for severity and progression in spinal cord injury reveals novel translational biomarker geneses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
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