Exploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMs

dc.contributor.affiliationInstituto de Instrumentación para Imagen Molecular
dc.contributor.authorLamprou, Efthymioses_ES
dc.contributor.authorGonzález Martínez, Antonio Javier
dc.contributor.authorF Sánchez
dc.contributor.authorBenlloch Baviera, Jose María
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.date.accessioned2021-02-25T04:49:06Z
dc.date.available2021-02-25T04:49:06Z
dc.date.issued2020-02es_ES
dc.description.abstract[EN] Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 x 50 x 15 mm(3) coupled to SiPM arrays (8 x 8 elements with 6 x 6 mm(2) area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 x 3 x 5 mm(3) LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationLamprou, E.; González Martínez, AJ.; Sánchez Martínez, F.; Benlloch Baviera, JM. (2020). Exploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMs. Physica Medica. 70:10-18. https://doi.org/10.1016/j.ejmp.2019.12.004es_ES
dc.description.referencesSurti, S. (2014). Update on Time-of-Flight PET Imaging. Journal of Nuclear Medicine, 56(1), 98-105. doi:10.2967/jnumed.114.145029es_ES
dc.description.referencesSpanoudaki, V. C., & Levin, C. S. (2010). Photo-Detectors for Time of Flight Positron Emission Tomography (ToF-PET). Sensors, 10(11), 10484-10505. doi:10.3390/s101110484es_ES
dc.description.referencesSzczesniak, T., Moszynski, M., Swiderski, L., Nassalski, A., Lavoute, P., & Kapusta, M. (2009). Fast Photomultipliers for TOF PET. IEEE Transactions on Nuclear Science, 56(1), 173-181. doi:10.1109/tns.2008.2008992es_ES
dc.description.referencesRenker, D. (2007). New trends on photodetectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 571(1-2), 1-6. doi:10.1016/j.nima.2006.10.016es_ES
dc.description.referencesKim, C. L., Wang, G.-C., & Dolinsky, S. (2009). Multi-Pixel Photon Counters for TOF PET Detector and Its Challenges. IEEE Transactions on Nuclear Science, 56(5), 2580-2585. doi:10.1109/tns.2009.2028075es_ES
dc.description.referencesMoses, W. W. (2002). Current trends in scintillator detectors and materials. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 487(1-2), 123-128. doi:10.1016/s0168-9002(02)00955-5es_ES
dc.description.referencesGundacker, S., Auffray, E., Pauwels, K., & Lecoq, P. (2016). Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Physics in Medicine and Biology, 61(7), 2802-2837. doi:10.1088/0031-9155/61/7/2802es_ES
dc.description.referencesGundacker, S., Acerbi, F., Auffray, E., Ferri, A., Gola, A., Nemallapudi, M. V., … Lecoq, P. (2016). State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs. Journal of Instrumentation, 11(08), P08008-P08008. doi:10.1088/1748-0221/11/08/p08008es_ES
dc.description.referencesSurti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007es_ES
dc.description.referencesGundacker, S., Knapitsch, A., Auffray, E., Jarron, P., Meyer, T., & Lecoq, P. (2014). Time resolution deterioration with increasing crystal length in a TOF-PET system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 737, 92-100. doi:10.1016/j.nima.2013.11.025es_ES
dc.description.referencesMarcinkowski, R., España, S., Van Holen, R., & Vandenberghe, S. (2014). Optimized light sharing for high-resolution TOF PET detector based on digital silicon photomultipliers. Physics in Medicine and Biology, 59(23), 7125-7139. doi:10.1088/0031-9155/59/23/7125es_ES
dc.description.referencesGonzález-Montoro, A., Sánchez, F., Martí, R., Hernández, L., Aguilar, A., Barberá, J., … González, A. J. (2018). Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 372-377. doi:10.1016/j.nima.2017.10.098es_ES
dc.description.referencesXi, D., Xie, Q., Zhu, J., Lin, L., Niu, M., Xiao, P., … Kao, C.-M. (2012). Optimization of the SiPM Pixel Size for a Monolithic PET Detector. Physics Procedia, 37, 1497-1503. doi:10.1016/j.phpro.2012.04.101es_ES
dc.description.referencesGonzalez-Montoro A, Aguilar A, Canizares G, Conde P, Hernandez L, Vidal LF, et al. Performance Study of a Large Monolithic LYSO PET Detector With Accurate Photon DOI Using Retroreflector Layers. IEEE Trans Rad Plasma Med Sci. PP. 1-1. DOI: 10.1109/TRPMS.2017.2692819.es_ES
dc.description.referencesKrishnamoorthy, S., Blankemeyer, E., Mollet, P., Surti, S., Van Holen, R., & Karp, J. S. (2018). Performance evaluation of the MOLECUBES β-CUBE—a high spatial resolution and high sensitivity small animal PET scanner utilizing monolithic LYSO scintillation detectors. Physics in Medicine & Biology, 63(15), 155013. doi:10.1088/1361-6560/aacec3es_ES
dc.description.referencesGonzález-Montoro, A., Sánchez, F., Bruyndonckx, P., Cañizares, G., Benlloch, J. M., & González, A. J. (2019). Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 920, 58-67. doi:10.1016/j.nima.2018.12.056es_ES
dc.description.referencesVan Dam, H. T., Borghi, G., Seifert, S., & Schaart, D. R. (2013). Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation. Physics in Medicine and Biology, 58(10), 3243-3257. doi:10.1088/0031-9155/58/10/3243es_ES
dc.description.referencesDi Francesco A, Bugalho R, Oliveira L, Pacher L, Rivetti A, Rolo M, et al. TOFPET2: A high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications. Journal of Instrumentation, vol. 11, no. 03, p. C03042.es_ES
dc.description.referencesTOFPET2 ASIC Evaluation kit - Hardware User Guide (v1.2), v1.2, PETsys Electronics SA., 2018.es_ES
dc.description.referencesLamprou, E., Aguilar, A., González-Montoro, A., Monzó, J. M., Cañizares, G., Iranzo, S., … Benlloch, J. M. (2018). PET detector block with accurate 4D capabilities. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 132-136. doi:10.1016/j.nima.2017.11.002es_ES
dc.description.referencesAcerbi, F., & Gundacker, S. (2019). Understanding and simulating SiPMs. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 926, 16-35. doi:10.1016/j.nima.2018.11.118es_ES
dc.description.referencesSchug D, Nadig V, Weissler B, Gebhardt P, Schulz V. Initial Measurements with the PETsys TOFPET2 ASIC Evaluation Kit and a Characterization of the ASIC TDC IEEE Trans Rad Plasma Med Sci. PP. 1-1. DOI: 10.1109/TRPMS.2018.2884564.es_ES
dc.description.referencesSeifert, S., van Dam, H. T., Vinke, R., Dendooven, P., Lohner, H., Beekman, F. J., & Schaart, D. R. (2012). A Comprehensive Model to Predict the Timing Resolution of SiPM-Based Scintillation Detectors: Theory and Experimental Validation. IEEE Transactions on Nuclear Science, 59(1), 190-204. doi:10.1109/tns.2011.2179314es_ES
dc.description.referencesVinke R, Olcott PD, Cates JW, Levin CS. The lower timing resolution bound for scintillators with non-negligible optical photon transport time in time-of-flight PET. Phys. Med. Phys. Med. Biol. 59 6215. Phys Med Biol. 2014; 59(20): 6215–29.es_ES
dc.description.referencesGonzalez AJ, Sanchez F, Benlloch JM. 2018 Organ-Dedicated Molecular Imaging Systems. IEEE Trans Ratiat Plasma Med Sci. 2017; 2(5): 388–403.es_ES
dc.description.sponsorshipThis project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 695536). It has also been supported by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R.es_ES
dc.description.upvformatpfin18es_ES
dc.description.upvformatpinicio10es_ES
dc.description.volume70es_ES
dc.identifier.doi10.1016/j.ejmp.2019.12.004es_ES
dc.identifier.issn1120-1797es_ES
dc.identifier.pmcidPMC7026714es_ES
dc.identifier.pmid31935602es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/162357
dc.languageIngléses_ES
dc.publisherElsevieres_ES
dc.relation.ispartofPhysica Medicaes_ES
dc.relation.pasarelaS\406022es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+i Orientado a los Retos de la Sociedad/TEC2016-79884-C2-1-R/Desarrollo del hardware para sistema de diagnóstico por imagen molecular para corazón en condiciones de estrés/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/695536/EU/Innovative PET scanner for dynamic imaging/es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.ejmp.2019.12.004es_ES
dc.relation.references10.2967/jnumed.114.145029es_ES
dc.relation.references10.3390/s101110484es_ES
dc.relation.references10.1109/TNS.2008.2008992es_ES
dc.relation.references10.1016/j.nima.2006.10.016es_ES
dc.relation.references10.1109/TNS.2009.2028075es_ES
dc.relation.references10.1016/S0168-9002(02)00955-5es_ES
dc.relation.references10.1088/0031-9155/61/7/2802es_ES
dc.relation.references10.1088/1748-0221/11/08/P08008es_ES
dc.relation.references10.1016/j.ejmp.2015.12.007es_ES
dc.relation.references10.1016/j.nima.2013.11.025es_ES
dc.relation.references10.1088/0031-9155/59/23/7125es_ES
dc.relation.references10.1016/j.nima.2017.10.098es_ES
dc.relation.references10.1016/j.phpro.2012.04.101es_ES
dc.relation.references10.1109/TRPMS.2017.2692819es_ES
dc.relation.references10.1088/1361-6560/aacec3es_ES
dc.relation.references10.1016/j.nima.2018.12.056es_ES
dc.relation.references10.1088/0031-9155/58/10/3243es_ES
dc.relation.references10.1088/1748-0221/11/03/C03042es_ES
dc.relation.references10.1016/j.nima.2017.11.002es_ES
dc.relation.references10.1016/j.nima.2018.11.118es_ES
dc.relation.references10.1109/TRPMS.2018.2884564es_ES
dc.relation.references10.1109/TNS.2011.2179314es_ES
dc.relation.references10.1088/0031-9155/59/20/6215es_ES
dc.relation.references10.1109/TRPMS.2018.2846745es_ES
dc.rightsReconocimiento - No comercial - Sin obra derivada (by-nc-nd)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectTOF-PETes_ES
dc.subjectMonolithic crystales_ES
dc.subjectASICes_ES
dc.subjectSiPMses_ES
dc.titleExploring TOF Capabilities of PET Detector Blocks Based on Large Monolithic Crystals and Analog SiPMses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
person.identifier407345
person.identifier468362
person.identifier396595
person.identifier.orcid0000-0001-6073-1436
relation.isAuthorOfPublication3484f0b6-dae3-4eb1-8694-1f189d247de8
relation.isAuthorOfPublication3796e255-4b46-4ab0-b24c-e3f5041efbc4
relation.isAuthorOfPublicationf19a2036-3a9b-49bf-a03b-85480ac291f2
relation.isAuthorOfPublication.latestForDiscovery3484f0b6-dae3-4eb1-8694-1f189d247de8
relation.isOrgUnitOfPublication2a147664-9b3c-4f73-8ea8-aefbad2ed456
relation.isOrgUnitOfPublication.latestForDiscovery2a147664-9b3c-4f73-8ea8-aefbad2ed456
upv.uuide5541df6-694a-409e-b880-a85ad99bbc65es_ES

Archivos

Bloque original

Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
Lamprou;González;Sánchez - Exploring TOF Capabilities of PET Detector Blocks Based on Large Monol....pdf
Tamaño:
1.41 MB
Formato:
Adobe Portable Document Format
Descripción:
Versión editorial