Bifidobacterium animalis subsp. lactis CECT 8145 BPL1® Laxative Effects in Loperamide-Induced Constipated SD Rats

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dc.contributor.authorRodenes-Gavidia, Andreaes_ES
dc.contributor.authorMas-Capdevilla, Annaes_ES
dc.contributor.authorFlorit, Adrianes_ES
dc.contributor.authorLopez, Maria Enriquees_ES
dc.contributor.authorGonzalez-Hedstrom, Danieles_ES
dc.contributor.authorLamelas, Aracelies_ES
dc.contributor.authorMartorell, Patriciaes_ES
dc.contributor.authorChenoll, Empares_ES
dc.contributor.authorIllescas-Armijo, Vanessaes_ES
dc.contributor.authorMartinez-Blanch, Juanes_ES
dc.contributor.authorAntolin, Annaes_ES
dc.contributor.authorAlcaide-Hidalgo, Juan Mariaes_ES
dc.contributor.authorMarine-Casado, Rogeres_ES
dc.contributor.authorRojas, Antoniaes_ES
dc.contributor.authorRago, Lauraes_ES
dc.date.accessioned2026-05-26T12:36:49Z
dc.date.available2026-05-26T12:36:49Z
dc.date.issued2026-04es_ES
dc.description.abstract[EN] Background: Constipation is a common gastrointestinal (GI) state for which probiotics have shown promise as a relief. This study examined the laxative effects of the strain Bifidobacterium animalis subsp. lactis CECT 8145 (BPL1 (R)) in a loperamide-induced rat model of constipation. Methods: Fifty-nine rats were divided into control and loperamide-induced constipation groups. Animals received a 3-day intervention with either placebo or probiotic BPL1 (R) at two doses: 1.5 & times; 108 CFU (colony-forming units) (low) and 3 & times; 109 CFU (high). The study assessed several parameters to determine the probiotic's effect, including: stool and gut characteristics, gastrointestinal transit time (GTT), gene expression and gut microbiome composition. Results: While loperamide significantly decreased stool number, weight and humidity, BPL1 (R) supplementation effectively restored these parameters, being more pronounced at a high dose. Microbiome analysis showed that BPL1 (R) at a low dose reduced the abundance of Muribaculaceae and Muribaculum gordoncarteri, associated with constipation. In addition, Muribaculaceae abundance was negatively correlated with stool humidity. Functional microbiome profiling indicated that BPL1 (R) suppressed pathways related to mucin degradation, vancomycin resistance and isoleucine biosynthesis while promoting L-lactate and pyridoxal-P (vitamin B6) biosynthesis, which may support gut motility and barrier integrity. Conclusions: Bifidobacterium animalis subsp. lactis BPL1 (R) exhibits potential as a functional probiotic for relieving constipation through improving stool excretion and consistency, inducing taxonomic changes and beneficial functional modulation of the intestinal microbiome. These findings justify further investigation into the mechanisms of BPL1 (R) as a probiotic for constipation management.es_ES
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationRodenes-Gavidia, A.; Mas-Capdevilla, A.; Florit, A.; Lopez, ME.; Gonzalez-Hedstrom, D.; Lamelas, A.; Martorell, P.... (2026). Bifidobacterium animalis subsp. lactis CECT 8145 BPL1® Laxative Effects in Loperamide-Induced Constipated SD Rats. Nutrients. 18(8). https://doi.org/10.3390/nu18081237es_ES
dc.description.issue8es_ES
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dc.description.volume18es_ES
dc.identifier.doi10.3390/nu18081237es_ES
dc.identifier.eissn2072-6643es_ES
dc.identifier.pmcidPMC13118976es_ES
dc.identifier.pmid42075050es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/235430
dc.languageIngléses_ES
dc.publisherMDPI AGes_ES
dc.relation.ispartofNutrientses_ES
dc.relation.pasarelaS\582317es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu18081237es_ES
dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectBifidobacterium animalis subsp. lactis CECT 8145es_ES
dc.subjectConstipationes_ES
dc.subjectProbioticses_ES
dc.subjectGut motilityes_ES
dc.subjectMicrobiome modulationes_ES
dc.titleBifidobacterium animalis subsp. lactis CECT 8145 BPL1® Laxative Effects in Loperamide-Induced Constipated SD Ratses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
upv.uuide5dd4cdf-be54-4f64-833f-3044f4e03115es_ES

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