Intra-ocular lens optical changes resulting from the loading of dexamethasone

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dc.contributor.affiliationInstituto Universitario Mixto de Tecnología Química
dc.contributor.authorArtigas, Jose M.es_ES
dc.contributor.authorGarcia-Domene, M. Carmenes_ES
dc.contributor.authorNavea, Amparoes_ES
dc.contributor.authorBOTELLA ASUNCION, PABLO
dc.contributor.authorFernandez, Eduardoes_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.contributor.funderEuropean Regional Development Fund
dc.date.accessioned2018-06-08T04:20:44Z
dc.date.available2018-06-08T04:20:44Z
dc.date.issued2017es_ES
dc.description.abstract[EN] To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationArtigas, JM.; Garcia-Domene, MC.; Navea, A.; Botella Asuncion, P.; Fernandez, E. (2017). Intra-ocular lens optical changes resulting from the loading of dexamethasone. Biomedical Optics Express. 8(10):4621-4628. https://doi.org/10.1364/BOE.8.004621es_ES
dc.description.issue10es_ES
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dc.description.sponsorshipProject IPT-2012-0574-300000 (Spain) and AJL Ophthalmic S.A. (Vitoria, Spain).es_ES
dc.description.upvformatpfin4628es_ES
dc.description.upvformatpinicio4621es_ES
dc.description.volume8es_ES
dc.identifier.doi10.1364/BOE.8.004621es_ES
dc.identifier.eissn2156-7085es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/103603
dc.languageIngléses_ES
dc.publisherOptical Society of Americaes_ES
dc.relation.ispartofBiomedical Optics Expresses_ES
dc.relation.pasarelaS\358642es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//IPT-2012-0574-300000/ES/Desarrollo de una nueva generación de lentes intraoculares multifuncionales(HORUS)/es_ES
dc.relation.publisherversionhttps://doi.org/10.1364/BOE.8.004621es_ES
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dc.relation.references10.1016/j.ophtha.2010.06.023es_ES
dc.relation.references10.1016/j.exer.2015.09.009es_ES
dc.relation.references10.1016/j.jcrs.2008.12.020es_ES
dc.relation.references10.1016/j.jcrs.2009.05.054es_ES
dc.relation.references10.1016/j.jcrs.2009.10.046es_ES
dc.relation.references10.1364/BOE.7.001877es_ES
dc.rightsReconocimiento (by)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.titleIntra-ocular lens optical changes resulting from the loading of dexamethasonees_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
person.identifier183997
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