Effect of phospholipid composition on the structure and physicochemical stability of proliposomes incorporating curcumin and cholecalciferol

[EN] Proliposomes are dry phospholipid-based particles in which bioactives can be entrapped, and that can produce liposomal suspensions if adequately hydrated. In our study, curcumin and cholecalciferol were incorporated in proliposomes obtained by coating of micronized sucrose. Different mass ratios of Lipoid S40 and Phospholipon 90H were used to produce the proliposomes. The powders were structurally characterized and bioactives content were analyzed over 60 days of storage. Curcumin and cholecalciferol amounts in F100CV formulation were 100 and 98.7% of their initial amount, respectively. Strucutral characterization showed bioactives were successfully incorporated in concentrations compatible with recommended daily dosages.