Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations

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dc.contributor.authorFares Riaño, Mario Alies_ES
dc.contributor.authorSabater-Muñoz, B.es_ES
dc.contributor.authorToft, C.es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderEuropean Regional Development Fundes_ES
dc.contributor.funderMinisterio de Economía y Competitividades_ES
dc.date.accessioned2020-09-12T03:35:17Z
dc.date.available2020-09-12T03:35:17Z
dc.date.issued2017-05-01es_ES
dc.description.abstract[EN] Gene duplication generates new genetic material, which has been shown to lead to major innovations in unicellular and multicellular organisms. A whole-genome duplication occurred in the ancestor of Saccharomyces yeast species but 92% of duplicates returned to single-copy genes shortly after duplication. The persisting duplicated genes in Saccharomyces led to the origin of major metabolic innovations, which have been the source of the unique biotechnological capabilities in the Baker's yeast Saccharomyces cerevisiae. What factors have determined the fate of duplicated genes remains unknown. Here, we report the first demonstration that the local genome mutation and transcription rates determine the fate of duplicates. We show, for the first time, a preferential location of duplicated genes in the mutational and transcriptional hotspots of S. cerevisiae genome. The mechanism of duplication matters, with whole-genome duplicates exhibiting different preservation trends compared to small-scale duplicates. Genome mutational and transcriptional hotspots are rich in duplicates with large repetitive promoter elements. Saccharomyces cerevisiae shows more tolerance to deleterious mutations in duplicates with repetitive promoter elements, which in turn exhibit higher transcriptional plasticity against environmental perturbations. Our data demonstrate that the genome traps duplicates through the accelerated regulatory and functional divergence of their gene copies providing a source of novel adaptations in yeast.en_EN
dc.description.accrualMethodSes_ES
dc.description.bibliographicCitationFares Riaño, MA.; Sabater-Muñoz, B.; Toft, C. (2017). Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations. Genome Biology and Evolution. 9(5):1229-1240. https://doi.org/10.1093/gbe/evx085es_ES
dc.description.issue5es_ES
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dc.description.sponsorshipThis study was supported by a grant (reference: FEDER-BFU2015-66073-P) from the Spanish Ministerio de Economia y Competitividad-FEDER and a grant (reference: ACOMP/2015/026) from the local government Conselleria de Educacion Investigacion, Cultura y Deporte, Generalitat Valenciana to M.A.F. C.T. was supported by a grant Juan de la Cierva from the Spanish Ministerio de Economia y Competitividad (reference: JCA-2012-14056).es_ES
dc.description.upvformatpfin1240es_ES
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dc.description.volume9es_ES
dc.identifier.doi10.1093/gbe/evx085es_ES
dc.identifier.issn1759-6653es_ES
dc.identifier.pmcidPMC5433386es_ES
dc.identifier.pmid28459980es_ES
dc.identifier.urihttps://riunet.upv.es/handle/10251/149960
dc.languageIngléses_ES
dc.publisherOxford University Presses_ES
dc.relation.ispartofGenome Biology and Evolutiones_ES
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dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2015-66073-P/ES/CARACTERIZANDO LOS MECANISMOS DE INNOVACION POR DUPLICACION GENICA/es_ES
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dc.relation.publisherversionhttps://doi.org/10.1093/gbe/evx085es_ES
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dc.rightsReconocimiento - No comercial (by-nc)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectGene duplicationes_ES
dc.subjectMutational genome hotspotses_ES
dc.subjectExpression genome hotspotses_ES
dc.subjectEnvironmental stresses_ES
dc.subjectPhenotypic plasticityes_ES
dc.subjectAdaptationses_ES
dc.subjectGenetic redundancyes_ES
dc.titleGenome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptationses_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
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