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Video approach to chemiluminescence detection using a low-cost complementary metal oxide semiconductor (CMOS)-based camera: determination of paracetamol in pharmaceutical formulations

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Video approach to chemiluminescence detection using a low-cost complementary metal oxide semiconductor (CMOS)-based camera: determination of paracetamol in pharmaceutical formulations

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dc.contributor.author Lahuerta-Zamora, Luis es_ES
dc.contributor.author Mellado Romero, Ana María es_ES
dc.date.accessioned 2018-04-13T04:13:10Z
dc.date.available 2018-04-13T04:13:10Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1618-2642 es_ES
dc.identifier.uri http://hdl.handle.net/10251/100326
dc.description.abstract [EN] A new system for continuous flow chemiluminescence detection, based on the use of a simple and low-priced lens-free digital camera (with complementary metal oxide semiconductor technology) as a detector, is proposed for the quantitative determination of paracetamol in commercial pharmaceutical formulations. Through the camera software, AVI video files of the chemiluminescence emission are captured and then, using friendly ImageJ public domain software (from National Institutes for Health), properly processed in order to extract the analytical information. The calibration graph was found to be linear over the range 0.01¿ 0.10 mg L¿1 and over the range 1.0¿100.0 mg L¿1 of paracetamol, the limit of detection being 10 ¿g L¿1. No significative interferences were found. Paracetamol was determined in three different pharmaceutical formulations: Termalgin®, Efferalgan® and Gelocatil®. The obtained results compared well with those declared on the formulation label and with those obtained through the official analytical method of British Pharmacopoeia. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Analytical and Bioanalytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Flow chemiluminescence es_ES
dc.subject CMOS camera es_ES
dc.subject ImageJ es_ES
dc.subject Pharmaceutical analysis es_ES
dc.subject.classification INGENIERIA DE LA CONSTRUCCION es_ES
dc.title Video approach to chemiluminescence detection using a low-cost complementary metal oxide semiconductor (CMOS)-based camera: determination of paracetamol in pharmaceutical formulations es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00216-017-0334-6 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de la Construcción y de Proyectos de Ingeniería Civil - Departament d'Enginyeria de la Construcció i de Projectes d'Enginyeria Civil es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s00216-017-0334-6 es_ES
dc.description.upvformatpinicio 3891 es_ES
dc.description.upvformatpfin 3898 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 409 es_ES
dc.description.issue 15 es_ES
dc.relation.pasarela S\348531 es_ES
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