Arnal Pastor, MP.; Vallés Lluch, A.; Keicher, M.; Monleón Pradas, M. (2011). Coating typologies and constrained swelling of hyaluronic acid gels within scaffold pores. Journal of Colloid and Interface Science. 361(1):361-369. https://doi.org/10.1016/j.jcis.2011.05.013
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/100811
Título:
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Coating typologies and constrained swelling of hyaluronic acid gels within scaffold pores
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Autor:
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Arnal Pastor, María Pilar
Vallés Lluch, Ana
Keicher, Matthias
Monleón Pradas, Manuel
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
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Fecha difusión:
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Resumen:
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[EN] A set of elastomeric scaffolds with a well defined porous structure was prepared with a template leaching procedure and coated with hyaluronic acid solutions. Depending on the coating process parameters the hyaluronic ...[+]
[EN] A set of elastomeric scaffolds with a well defined porous structure was prepared with a template leaching procedure and coated with hyaluronic acid solutions. Depending on the coating process parameters the hyaluronic acid deposited on the pores had configurations ranging from thin disconnected aggregates to a thick continuous layer on the pore surface. The development of the coating layer was studied by scanning electron microscopy and the materials were subjected to dynamical and equilibrium swelling experiments in a water vapor ambient of fixed activity. The porosity change due to coating and to swelling of the coating layer were determined. The hyaluronic acid coating the pores has a different swelling capacity depending on the type of layer formed, as a consequence of the scaffold constraint and of the layer typology. These factors were investigated analytically by modifying the standard theory of gel swelling. An experimental quantity is introduced which reflects the constrainment build-up on gel swelling. © 2011 Elsevier Inc.
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Palabras clave:
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Hyaluronic acid/hyaluronan
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Scaffold
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Swelling
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Coating layer
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Coating process parameter
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Continuous layers
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Elastomeric scaffolds
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Equilibrium swelling
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Gel swelling
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Hyaluronic acid coatings
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Hyaluronic acids
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Leaching procedures
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Pore surface
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Porosity changes
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Porous structures
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Standard theories
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Swelling capacities
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Agglomeration
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Coatings
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Gels
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Leaching
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Organic acids
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Scaffolds
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Scaffolds (biology)
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Scanning electron microscopy
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Tissue
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Water vapor
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Acrylic acid derivative
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Elastomer
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hyaluronic acid
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Molecular scaffold
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poly(ethyl acrylate)
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Unclassified drug
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Adsorption
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Article
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Chemical structure
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Controlled study
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Elasticity
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Gel
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Heart
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Humidity
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Material coating
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Porosity
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Priority journal
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Surface property
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Coated Materials, Biocompatible
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Tissue Scaffolds
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Water
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Derechos de uso:
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Reserva de todos los derechos
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Fuente:
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Journal of Colloid and Interface Science. (issn:
0021-9797
)
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DOI:
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10.1016/j.jcis.2011.05.013
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Editorial:
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Elsevier
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Versión del editor:
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https://doi.org/10.1016/j.jcis.2011.05.013
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Código del Proyecto:
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info:eu-repo/grantAgreement/EC/FP7/229239/EU/Regeneration of Cardiac Tissue Assisted by Bioactive Implants/
info:eu-repo/grantAgreement/MICINN//MAT2008-06434/ES/MATERIALES PARA REGENERACION NEURAL Y ANGIOGENESIS EN EL SISTEMA NERVIOSO CENTRAL/
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Agradecimientos:
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The authors acknowledge the support of the FP7 NMP3-SL-2009-229239 project "Regeneration of cardiac tissue assisted by bioactive implants (RECATABI)". MMP further acknowledges the support of the Spanish Science & Innovation ...[+]
The authors acknowledge the support of the FP7 NMP3-SL-2009-229239 project "Regeneration of cardiac tissue assisted by bioactive implants (RECATABI)". MMP further acknowledges the support of the Spanish Science & Innovation Ministry through project MAT2008-06434. Roberto Garcia Gomez is thanked for his help in preparing the bare scaffolds.
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Tipo:
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Artículo
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