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High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

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High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

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dc.contributor.author Ruiz-Tórtola, Ángela es_ES
dc.contributor.author Prats-Quílez, Francisco es_ES
dc.contributor.author Gonzalez-Lucas, Daniel es_ES
dc.contributor.author Bañuls Polo, María-José es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.contributor.author Wheeler, Guy es_ES
dc.contributor.author Dalmay, Tamas es_ES
dc.contributor.author Griol Barres, Amadeu es_ES
dc.contributor.author Hurtado Montañés, Juan es_ES
dc.contributor.author García-Rupérez, Jaime es_ES
dc.date.accessioned 2018-05-06T04:15:52Z
dc.date.available 2018-05-06T04:15:52Z
dc.date.issued 2018 es_ES
dc.identifier.uri http://hdl.handle.net/10251/101449
dc.description.abstract [EN] A label-free sensor, based on the combination of silicon photonic bandgap (PBG) structures with immobilized molecular beacon (MB) probes, is experimentally developed. Complementary target oligonucleotides are specifically recognized through hybridization with the MB probes on the surface of the sensing structure. This combination of PBG sensing structures and MB probes demonstrates an extremely high sensitivity without the need for complex PCR-based amplification or labelling methods. es_ES
dc.description.sponsorship European Commission through the Horizon 2020 Program (ICT-644242 SAPHELY project).
dc.language Inglés es_ES
dc.publisher Optical Society of America es_ES
dc.relation.ispartof Biomedical Optics Express es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Mach-zehnder interferometer es_ES
dc.subject Microring resonators es_ES
dc.subject Multiplexed detection es_ES
dc.subject Optical biosensors es_ES
dc.subject Binding-kinetics es_ES
dc.subject Hybridization es_ES
dc.subject.classification TEORIA DE LA SEÑAL Y COMUNICACIONES es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1364/BOE.9.001717 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/644242/EU/Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Tecnología Nanofotónica - Institut Universitari de Tecnologia Nanofotònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Ruiz-Tórtola, Á.; Prats-Quílez, F.; Gonzalez-Lucas, D.; Bañuls Polo, M.; Maquieira Catala, Á.; Wheeler, G.; Dalmay, T.... (2018). High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes. Biomedical Optics Express. 9(4):1717-1727. https://doi.org/10.1364/BOE.9.001717 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1364/BOE.9.001717 es_ES
dc.description.upvformatpinicio 1717 es_ES
dc.description.upvformatpfin 1727 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 4 es_ES
dc.identifier.eissn 2156-7085 es_ES
dc.identifier.pmid 29675313 en_EN
dc.identifier.pmcid PMC5905917 en_EN
dc.relation.pasarela S\355501 es_ES
dc.contributor.funder European Commission es_ES
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