Chorro Gasco, FJ.; Ibañez Catala, X.; Trapero, I.; Such-Miquel, LM.; Pelechano, F.; Cánoves, J.; Mainar Latorre, L.... (2013). Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions. Pacing and Clinical Electrophysiology. 36(3):286-298. https://doi.org/10.1111/pace.12060
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/104251
Title:
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Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions
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Author:
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CHORRO GASCO, FCO JAVIER
Ibañez Catala, Xavier
TRAPERO, ISABEL
SUCH-MIQUEL, LUIS M
PELECHANO, FRANCISCA
CÁNOVES, JOAQUÍN
MAINAR LATORRE, LUIS
CERDA, JOSE M.
Tormos Ferrando, Álvaro
ALBEROLA, ANTONIO
SUCH, L
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UPV Unit:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
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Issued date:
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Abstract:
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[EN] Background: Selective local acceleration of myocardial activation during ventricular fibrillation (VF)
contributes information on the interactions between neighboring zones during the arrhythmia. This
study analyzes ...[+]
[EN] Background: Selective local acceleration of myocardial activation during ventricular fibrillation (VF)
contributes information on the interactions between neighboring zones during the arrhythmia. This
study analyzes these interactions, centering the observations on an isthmus of myocardium between
two radiofrequency (RF) lesions.
Methods: In nine isolated rabbit hearts, a gap of preserved myocardium was established between two
RF lesions in the anterolateral left ventricle (LV) wall. Before, during, and after increasing the spatial
heterogeneity of VF by local myocardial stretching, VF epicardial recordings were obtained.
Results: Local stretch in the anterior LV wall decreased the excitable window (17 ±7ms vs 26 ±7ms; P
< 0.05) and increased the dominant frequency (DFr; 18.9 ± 5.0 Hz vs 15.2 ± 3.6 Hz; P < 0.05) in this zone,
without changes in the non-stretched posterolateral zone (25 ±4ms vs 27 ± 6 ms, ns and 14.1 ± 2.7 Hz vs
14.3 ± 3.0 Hz, ns). The DFr ratio at both sides of the gap was inversely correlated to the excitable window
ratio (R = ¿0.57; P = 0.002). Before (31% vs 26%), during (29% vs 22%), and after stretch suppression
(35% vs 25%), the wavefronts passing through the gap from the posterolateral to the anterior LV wall
were seen to predominate. The number of wavefronts that passed from the anterior to the posterolateral
LV wall was related to the excitable window in this zone (R = 0.41; P = 0.03).
Conclusions: The VF acceleration induced in the stretched zone does not increase the flow of wavefronts
toward the non-stretched zone in the adjacent gap of preserved myocardium. The absence of significant
changes in the electrophysiological parameters of the non-stretched myocardium limits the arrival of
wavefronts in this zone. (PACE 2013; 36:286¿298)
[-]
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Subjects:
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Cardiac mapping
,
mechanical stretch
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myocardial activation
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radiofrequency
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spectral analysis
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ventricular fibrillation
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Copyrigths:
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Cerrado |
Source:
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Pacing and Clinical Electrophysiology. (issn:
0147-8389
)
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DOI:
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10.1111/pace.12060
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Publisher:
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WILEY-BLACKWELL
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Publisher version:
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https://doi.org/10.1111/pace.12060
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Project ID:
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info:eu-repo/grantAgreement/MICINN//PS09%2F02417/ES/MODIFICACIONES FARMACOLOGICAS DE LOS EFECTOS ELECTROFISIOLOGICOS DEL ESTIRAMIENTO MIOCARDICO/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F093/ES/Análisis de los efectos de las modificaciones electrofisiológicas sobre los procesos fibrilatorios/
info:eu-repo/grantAgreement/MSC//RD06%2F0003%2F0010/ES/RED DE INVESTIGACIÓN EN INSUFICIENCIA CARDIACA EN ESPAÑA (REDINSCOR)/
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Thanks:
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Grants: This work was supported by Spanish Ministry of Science "Instituto de Salud Carlos III" Grants FIS PS09/02417 and RETIC REDINSCOR RD06/0003/0010, and by "Generalitat Valenciana" Grant PROMETEO 2010/093.
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Type:
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Artículo
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