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Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions

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Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions

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dc.contributor.author CHORRO GASCO, FCO JAVIER es_ES
dc.contributor.author Ibañez Catala, Xavier es_ES
dc.contributor.author TRAPERO, ISABEL es_ES
dc.contributor.author SUCH-MIQUEL, LUIS M es_ES
dc.contributor.author PELECHANO, FRANCISCA es_ES
dc.contributor.author CÁNOVES, JOAQUÍN es_ES
dc.contributor.author MAINAR LATORRE, LUIS es_ES
dc.contributor.author CERDA, JOSE M. es_ES
dc.contributor.author Tormos Ferrando, Álvaro es_ES
dc.contributor.author ALBEROLA, ANTONIO es_ES
dc.contributor.author SUCH, L es_ES
dc.date.accessioned 2018-06-18T04:24:45Z
dc.date.available 2018-06-18T04:24:45Z
dc.date.issued 2013 es_ES
dc.identifier.issn 0147-8389 es_ES
dc.identifier.uri http://hdl.handle.net/10251/104251
dc.description.abstract [EN] Background: Selective local acceleration of myocardial activation during ventricular fibrillation (VF) contributes information on the interactions between neighboring zones during the arrhythmia. This study analyzes these interactions, centering the observations on an isthmus of myocardium between two radiofrequency (RF) lesions. Methods: In nine isolated rabbit hearts, a gap of preserved myocardium was established between two RF lesions in the anterolateral left ventricle (LV) wall. Before, during, and after increasing the spatial heterogeneity of VF by local myocardial stretching, VF epicardial recordings were obtained. Results: Local stretch in the anterior LV wall decreased the excitable window (17 ±7ms vs 26 ±7ms; P < 0.05) and increased the dominant frequency (DFr; 18.9 ± 5.0 Hz vs 15.2 ± 3.6 Hz; P < 0.05) in this zone, without changes in the non-stretched posterolateral zone (25 ±4ms vs 27 ± 6 ms, ns and 14.1 ± 2.7 Hz vs 14.3 ± 3.0 Hz, ns). The DFr ratio at both sides of the gap was inversely correlated to the excitable window ratio (R = ¿0.57; P = 0.002). Before (31% vs 26%), during (29% vs 22%), and after stretch suppression (35% vs 25%), the wavefronts passing through the gap from the posterolateral to the anterior LV wall were seen to predominate. The number of wavefronts that passed from the anterior to the posterolateral LV wall was related to the excitable window in this zone (R = 0.41; P = 0.03). Conclusions: The VF acceleration induced in the stretched zone does not increase the flow of wavefronts toward the non-stretched zone in the adjacent gap of preserved myocardium. The absence of significant changes in the electrophysiological parameters of the non-stretched myocardium limits the arrival of wavefronts in this zone. (PACE 2013; 36:286¿298) es_ES
dc.description.sponsorship Grants: This work was supported by Spanish Ministry of Science "Instituto de Salud Carlos III" Grants FIS PS09/02417 and RETIC REDINSCOR RD06/0003/0010, and by "Generalitat Valenciana" Grant PROMETEO 2010/093. en_EN
dc.language Inglés es_ES
dc.publisher WILEY-BLACKWELL es_ES
dc.relation.ispartof Pacing and Clinical Electrophysiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cardiac mapping es_ES
dc.subject mechanical stretch es_ES
dc.subject myocardial activation es_ES
dc.subject radiofrequency es_ES
dc.subject spectral analysis es_ES
dc.subject ventricular fibrillation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/pace.12060 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PS09%2F02417/ES/MODIFICACIONES FARMACOLOGICAS DE LOS EFECTOS ELECTROFISIOLOGICOS DEL ESTIRAMIENTO MIOCARDICO/
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F093/ES/Análisis de los efectos de las modificaciones electrofisiológicas sobre los procesos fibrilatorios/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MSC//RD06%2F0003%2F0010/ES/RED DE INVESTIGACIÓN EN INSUFICIENCIA CARDIACA EN ESPAÑA (REDINSCOR)/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Chorro Gasco, FJ.; Ibañez Catala, X.; Trapero, I.; Such-Miquel, LM.; Pelechano, F.; Cánoves, J.; Mainar Latorre, L.... (2013). Ventricular fibrillation conduction through an isthmus of preserved myocardium between radiofrequency lesions. Pacing and Clinical Electrophysiology. 36(3):286-298. https://doi.org/10.1111/pace.12060 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/pace.12060 es_ES
dc.description.upvformatpinicio 286 es_ES
dc.description.upvformatpfin 298 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 36 es_ES
dc.description.issue 3 es_ES
dc.relation.pasarela S\243392 es_ES
dc.contributor.funder Instituto de Salud Carlos III
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Ministerio de Sanidad y Consumo


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