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Extracellular matrix inspired gelatin/hyaluronic acid injectable hydrogels

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Extracellular matrix inspired gelatin/hyaluronic acid injectable hydrogels

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dc.contributor.author Sanmartín-Masiá, Esther es_ES
dc.contributor.author Poveda-Reyes, Sara es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.date.accessioned 2018-09-17T07:19:00Z
dc.date.available 2018-09-17T07:19:00Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0091-4037 es_ES
dc.identifier.uri http://hdl.handle.net/10251/107376
dc.description.abstract [EN] Gelatin injectable hydrogels have attracted attention for soft tissues regeneration; however, their poor mechanical properties limit their applications. The authors present a versatile strategy to enhance mechanical properties by mixing gelatin (Gel) with different proportions of hyaluronic acid (HA). The protein-polysaccharide systems are inspired by extracellular matrix and benefit from adhesive properties of RGD sequences in Gel and enhanced hydration and stiffness of HA. The authors were able to raise the Young s modulus from 4kPa to 6kPa and gelation times can be tuned between 4 to 9 min, giving surgeons the option of adapting the material to specific requirements. es_ES
dc.description.sponsorship The authors are grateful for the financial support received from the Spanish Ministry of Economy and Competitiveness through the MAT2013-46467-C4-1-R Project (including Feder funds) and the BES-2011-046144 grant. The CIBER-BBN initiative is funded by the VI National R&D&I Plan 2008-2011, "Iniciativa Ingenio 2010," Consolider Program. CIBER actions are financed by the "Instituto de Salud Carlos III" with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation.ispartof International Journal of Polymeric Materials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Enhanced mechanical properties es_ES
dc.subject Enzymatic crosslinking es_ES
dc.subject Gelatin es_ES
dc.subject Hyaluronic acid es_ES
dc.subject Injectable hydrogels es_ES
dc.subject Protein-polysaccharide hydrogel es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.title Extracellular matrix inspired gelatin/hyaluronic acid injectable hydrogels es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/00914037.2016.1201828 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BES-2011-046144/ES/BES-2011-046144/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Sanmartín-Masiá, E.; Poveda-Reyes, S.; Gallego Ferrer, G. (2017). Extracellular matrix inspired gelatin/hyaluronic acid injectable hydrogels. International Journal of Polymeric Materials. 66(6):280-288. https://doi.org/10.1080/00914037.2016.1201828 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1080/00914037.2016.1201828 es_ES
dc.description.upvformatpinicio 280 es_ES
dc.description.upvformatpfin 288 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 66 es_ES
dc.description.issue 6 es_ES
dc.relation.pasarela S\328692 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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