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Bioactive organic inorganic poly(CLMA-co-HEA)/silica nanocomposites

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Bioactive organic inorganic poly(CLMA-co-HEA)/silica nanocomposites

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dc.contributor.author Ivashchenko, Sergiy es_ES
dc.contributor.author Escobar Ivirico, Jorge Luis es_ES
dc.contributor.author García Cruz, Dunia Mercedes es_ES
dc.contributor.author Campillo Fernández, Alberto José es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.date.accessioned 2018-09-29T04:32:12Z
dc.date.available 2018-09-29T04:32:12Z
dc.date.issued 2015 es_ES
dc.identifier.issn 0885-3282 es_ES
dc.identifier.uri http://hdl.handle.net/10251/108615
dc.description.abstract [EN] A series of novel poly(CLMA-co-HEA)/silica nanocomposites is synthesized from caprolactone 2-(methacryloyloxy)ethyl ester (CLMA) and 2-hydroxyethyl acrylate (HEA) as organic comonomers and the simultaneous sol-gel polymerization of tetraethyloxysilane (TEOS) as silica precursor, in different mass ratios up to a 30 wt% of silica. The nanocomposites are characterized as to their mechanical and thermal properties, water sorption, bioactivity and biocompatibility, reflecting the effect on the organic matrix provided by the silica network formation. The nanocomposites nucleate the growth of hydroxyapatite (HAp) on their surfaces when immersed in the simulated body fluid of the composition used in this work. Proliferation of the MC3T3 osteoblast-like cells on the materials was assessed with the MTS assay showing their biocompatibility. Immunocytochemistry reveals osteocalcin and type I collagen production, indicating that osteoblast differentiation was promoted by the materials, and calcium deposition was confirmed by von Kossa staining. The results indicate that these poly(CLMA-co-HEA)/silica nanocomposites could be a promising biomaterial for bone tissue engineering. es_ES
dc.description.sponsorship The authors acknowledge the financial support from the Spanish Ministry of Science and Innovation through projects DPI2010-20399-c04-03 and MAT2011-28791-C03-02. AJCF acknowledges support through Torres Quevedo grant PTQ08-02-06321. GGF and MMP acknowledge support of CIBER-BBN initiative, financed by Instituto de Salud Carlos III (Spain) with the assistance of the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher SAGE Publications es_ES
dc.relation.ispartof Journal of Biomaterials Applications es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nanocomposites es_ES
dc.subject Organic polymer es_ES
dc.subject Silica es_ES
dc.subject Bioactivity es_ES
dc.subject Biocompatibility es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Bioactive organic inorganic poly(CLMA-co-HEA)/silica nanocomposites es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1177/0885328214554816 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-02/ES/MATERIALES DE SOPORTE Y LIBERACION CONTROLADA PARA LA REGENERACION DE ESTRUCTURAS NEURALES AFECTADAS POR ICTUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-03/ES/DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAFFOLD%2FSOPORTE PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PTQ-08-02-06321/ES/PTQ-08-02-06321/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Ivashchenko, S.; Escobar Ivirico, JL.; García Cruz, DM.; Campillo Fernández, AJ.; Gallego Ferrer, G.; Monleón Pradas, M. (2015). Bioactive organic inorganic poly(CLMA-co-HEA)/silica nanocomposites. Journal of Biomaterials Applications. 29(8):1096-1108. https://doi.org/10.1177/0885328214554816 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1177/0885328214554816 es_ES
dc.description.upvformatpinicio 1096 es_ES
dc.description.upvformatpfin 1108 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 29 es_ES
dc.description.issue 8 es_ES
dc.relation.pasarela S\277441 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder Instituto de Salud Carlos III
dc.contributor.funder European Regional Development Fund
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