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Ambient temperature drying of therapeutic protein solution with use of microwave

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Ambient temperature drying of therapeutic protein solution with use of microwave

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dc.contributor.author Tsuruta, Takaharu es_ES
dc.contributor.author Ogawa, Takuma es_ES
dc.contributor.author Abe, Ryosuke es_ES
dc.contributor.author Tanigawa, Hirofumi es_ES
dc.date.accessioned 2019-03-11T08:25:51Z
dc.date.available 2019-03-11T08:25:51Z
dc.date.issued 2018-09-07
dc.identifier.isbn 9788490486887
dc.identifier.uri http://hdl.handle.net/10251/117936
dc.description.abstract [EN] High quality drying of therapeutic protein-solution is important in medical and pharmaceutical processing. Freeze-drying is mostly used, but it takes a long drying-time and causes damages of protein structures. In order to improve the drying quality, we propose a microwave vacuum drying performed at ambient temperatures under low-pressure conditions. We are focusing on the Parma-Zyme method for the evaporative drying of protein solutions such as egg white or lysozyme with vitrification. Circular dichroism (CD) spectroscopy is used to detect protein conformation changes due to the drying, and it is found that the ambient temperature drying can preserve the protein conformation. es_ES
dc.description.sponsorship CD analysis and chemical works were supported by Prof. Shigeori Takenaka, Department of Applied Chemistry, Kyushu Institute of Technology. This study was financially supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research, Project No. 17K18843. es_ES
dc.format.extent 8 es_ES
dc.language Inglés es_ES
dc.publisher Editorial Universitat Politècnica de València es_ES
dc.relation.ispartof IDS 2018. 21st International Drying Symposium Proceedings es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Drying es_ES
dc.subject Dehydration es_ES
dc.subject Dewatering es_ES
dc.subject Emerging technologies es_ES
dc.subject Products quality es_ES
dc.subject Process control es_ES
dc.subject Environmental es_ES
dc.subject Evaporation es_ES
dc.subject Sublimation es_ES
dc.subject Diffusion es_ES
dc.subject Energy es_ES
dc.subject Intensification es_ES
dc.subject Microwave vacuum drying es_ES
dc.subject Freeze-drying es_ES
dc.subject Therapeutic protein es_ES
dc.subject Egg white es_ES
dc.subject Lysozyme es_ES
dc.title Ambient temperature drying of therapeutic protein solution with use of microwave es_ES
dc.type Capítulo de libro es_ES
dc.type Comunicación en congreso es_ES
dc.identifier.doi 10.4995/IDS2018.2018.7537
dc.relation.projectID info:eu-repo/grantAgreement/MEXT//17K18843/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Tsuruta, T.; Ogawa, T.; Abe, R.; Tanigawa, H. (2018). Ambient temperature drying of therapeutic protein solution with use of microwave. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 651-658. https://doi.org/10.4995/IDS2018.2018.7537 es_ES
dc.description.accrualMethod OCS es_ES
dc.relation.conferencename 21st International Drying Symposium es_ES
dc.relation.conferencedate Septiembre 11-14, 2018 es_ES
dc.relation.conferenceplace Valencia, Spain es_ES
dc.relation.publisherversion http://ocs.editorial.upv.es/index.php/IDS/ids2018/paper/view/7537 es_ES
dc.description.upvformatpinicio 651 es_ES
dc.description.upvformatpfin 658 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.pasarela OCS\7537 es_ES
dc.contributor.funder Ministry of Education, Culture, Sports, Science and Technology, Japón es_ES


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