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Generation of high drug loading amorphous solid dispersions by Spray Drying

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Generation of high drug loading amorphous solid dispersions by Spray Drying

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dc.contributor.author Costa, Bhianca es_ES
dc.contributor.author Sauceau, Martial es_ES
dc.contributor.author Sescousse, Romain es_ES
dc.contributor.author Re, Maria es_ES
dc.date.accessioned 2019-03-14T09:07:47Z
dc.date.available 2019-03-14T09:07:47Z
dc.date.issued 2018-09-07
dc.identifier.isbn 9788490486887
dc.identifier.uri http://hdl.handle.net/10251/118124
dc.description.abstract [EN] Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus®. Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%. es_ES
dc.format.extent 8 es_ES
dc.language Inglés es_ES
dc.publisher Editorial Universitat Politècnica de València es_ES
dc.relation.ispartof IDS 2018. 21st International Drying Symposium Proceedings es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Drying es_ES
dc.subject Dehydration es_ES
dc.subject Dewatering es_ES
dc.subject Emerging technologies es_ES
dc.subject Products quality es_ES
dc.subject Process control es_ES
dc.subject Environmental es_ES
dc.subject Evaporation es_ES
dc.subject Sublimation es_ES
dc.subject Diffusion es_ES
dc.subject Energy es_ES
dc.subject Intensification es_ES
dc.subject Amorphous solid dispersion es_ES
dc.subject Spray drying es_ES
dc.subject High drug loading es_ES
dc.subject Soluplus es_ES
dc.subject Efavirenz es_ES
dc.title Generation of high drug loading amorphous solid dispersions by Spray Drying es_ES
dc.type Capítulo de libro es_ES
dc.type Comunicación en congreso es_ES
dc.identifier.doi 10.4995/IDS2018.2018.7871
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Costa, B.; Sauceau, M.; Sescousse, R.; Re, M. (2018). Generation of high drug loading amorphous solid dispersions by Spray Drying. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 1123-1130. https://doi.org/10.4995/IDS2018.2018.7871 es_ES
dc.description.accrualMethod OCS es_ES
dc.relation.conferencename 21st International Drying Symposium es_ES
dc.relation.conferencedate Septiembre 11-14, 2018 es_ES
dc.relation.conferenceplace Valencia, Spain es_ES
dc.relation.publisherversion http://ocs.editorial.upv.es/index.php/IDS/ids2018/paper/view/7871 es_ES
dc.description.upvformatpinicio 1123 es_ES
dc.description.upvformatpfin 1130 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.pasarela OCS\7871 es_ES


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