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Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes

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Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes

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dc.contributor.author Ruiz-Tórtola, Ángela es_ES
dc.contributor.author Prats-Quílez, Francisco es_ES
dc.contributor.author Gonzalez-Lucas, Daniel es_ES
dc.contributor.author Bañuls Polo, María-José es_ES
dc.contributor.author Maquieira Catala, Angel es_ES
dc.contributor.author Wheeler, Guy es_ES
dc.contributor.author Dalmay, Tamas es_ES
dc.contributor.author Griol Barres, Amadeu es_ES
dc.contributor.author Hurtado Montañés, Juan es_ES
dc.contributor.author Bohlmann, Helge es_ES
dc.contributor.author Götzen, Reiner es_ES
dc.contributor.author García-Rupérez, Jaime es_ES
dc.date.accessioned 2020-02-12T21:01:38Z
dc.date.available 2020-02-12T21:01:38Z
dc.date.issued 2018 es_ES
dc.identifier.issn 1864-063X es_ES
dc.identifier.uri http://hdl.handle.net/10251/136756
dc.description.abstract [EN] An experimental study of the influence of the conformational change suffered by molecular beacon (MB) probesupon the biorecognition of nucleic acid target oligonucleotides over evanescent wave photonic sensorsis reported. To this end, high sensitivity photonic sensors based on silicon photonic bandgap (PBG) structures were used, where the MB probes were immobilized via their 5 termination. Those MBs incorporate a biotin moiety close to their 3 termination in order to selectively bind a streptavidin molecule to them. The different photonic sensing responses obtained toward the target oligonucleotide detection, when the streptavidin molecule was bound to the MB probes or not, demonstrate the conformational change suffered by the MB upon hybridization, which promotes the displacement of the streptavidin molecule away from the surface of the photonic sensing structure. es_ES
dc.description.sponsorship Horizon 2020 Framework Programme, Grant/Award Number: ICT-644242; MINECO, Grant/Award Number: CTQ/2016/75749-R es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation CEE/644242 es_ES
dc.relation AEI/CTQ2016-75749-R es_ES
dc.relation.ispartof Journal of Biophotonics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Conformational change es_ES
dc.subject Molecular beacon es_ES
dc.subject Photonic bandgap es_ES
dc.subject Photonic biosensor es_ES
dc.subject Silicon photonics es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification TEORIA DE LA SEÑAL Y COMUNICACIONES es_ES
dc.title Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbio.201800030 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Tecnología Nanofotónica - Institut Universitari de Tecnologia Nanofotònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Ruiz-Tórtola, Á.; Prats-Quílez, F.; Gonzalez-Lucas, D.; Bañuls Polo, M.; Maquieira Catala, A.; Wheeler, G.; Dalmay, T.... (2018). Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes. Journal of Biophotonics. 11(10). https://doi.org/10.1002/jbio.201800030 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/jbio.201800030 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 10 es_ES
dc.relation.pasarela S\366788 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Commission es_ES


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