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Genome-wide association study for intramuscular fatty acid composition in an Iberian x Landrace cross

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Genome-wide association study for intramuscular fatty acid composition in an Iberian x Landrace cross

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dc.contributor.author Ramayo-Caldas, Y. es_ES
dc.contributor.author Mercadé, A. es_ES
dc.contributor.author Castelló, A. es_ES
dc.contributor.author Yang, B. es_ES
dc.contributor.author Rodríguez, C. es_ES
dc.contributor.author Alves, E. es_ES
dc.contributor.author Díaz, I. es_ES
dc.contributor.author Ibáñez-Escriche, Noelia es_ES
dc.contributor.author Noguera, J. L. es_ES
dc.contributor.author Pérez-Enciso, M. es_ES
dc.contributor.author Fernández, A. I. es_ES
dc.contributor.author Folch, J. M. es_ES
dc.date.accessioned 2020-03-16T14:46:52Z
dc.date.available 2020-03-16T14:46:52Z
dc.date.issued 2012-09 es_ES
dc.identifier.issn 0021-8812 es_ES
dc.identifier.uri http://hdl.handle.net/10251/138963
dc.description.abstract [EN] The lipid content and fatty acid (FA) profile have an important impact in human health as well as in the technological transformation and nutritional and organoleptic quality of meat. A genome-wide association study (GWAS) on 144 backcross pigs (25% Iberian x 75% Landrace) was performed for 32 traits associated with intramuscular FA composition and indices of FA metabolism. The GWAS was carried out using Qxpak 5.0 and the genotyping information obtained from the Porcine SNP60K BeadChip (Illumina Inc., San Diego, CA). Signals of significant association considering a false-discovery rate (q-value < 0.05) were observed in 15 of the 32 analyzed traits, and a total of 813 trait-associated SNP (TAS), distributed in 43 chromosomal intervals on almost all autosomes, were annotated. According to the clustering analysis based on functional classification, several of the annotated genes are related to FA composition and lipid metabolism. Some interesting positional concordances among TAS and previously reported QTL for FA compositions and/or other lipid traits were also found. These common genomic regions for different traits suggest pleiotropic effects for FA composition and were found primarily on SSC4, SSC8, and SSC16. These results contribute to our understanding of the complex genetic basis of FA composition and FA metabolism. es_ES
dc.description.sponsorship This work was funded by MICINN Project AGL2008-04818-C03/GAN (Spanish Ministry of Science) and by the Innovation Consolider-Ingenio 2010 Program (CSD2007-00036, Centre for Research in Agrigenomics). We are indebted to Nova Genetica (Lleida, Spain) and its staff for their technical support. Y. Ramayo-Caldas was funded by a FPU Ph.D. grant from the Spanish Ministerio de Educacion (AP2008-01450). We thank Joaquin Casellas (UAB) and Jordi Estelle (INRA Jouy-en-Josas) for their comments, and also Martien Groenen (Wageningen, NL) for providing information about SNP positioning in Assembly 10. This manuscript has been proofread by Chuck Simons, a native English-speaking university instructor of English. es_ES
dc.language Inglés es_ES
dc.publisher American Society of Animal Science es_ES
dc.relation MICINN/AGL2008-04818-C03/GAN es_ES
dc.relation MECD/AP2008-01450 es_ES
dc.relation MICINN/CSD2007-00036 es_ES
dc.relation.ispartof Journal of Animal Science es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Candidate gene es_ES
dc.subject Fatty acid es_ES
dc.subject Genome-wide association study es_ES
dc.subject Intramuscular fat es_ES
dc.subject Meat quality es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Genome-wide association study for intramuscular fatty acid composition in an Iberian x Landrace cross es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.2527/jas.2011-4900 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Ramayo-Caldas, Y.; Mercadé, A.; Castelló, A.; Yang, B.; Rodríguez, C.; Alves, E.; Díaz, I.... (2012). Genome-wide association study for intramuscular fatty acid composition in an Iberian x Landrace cross. Journal of Animal Science. 90(9):2883-2893. https://doi.org/10.2527/jas.2011-4900 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.2527/jas.2011-4900 es_ES
dc.description.upvformatpinicio 2883 es_ES
dc.description.upvformatpfin 2893 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 90 es_ES
dc.description.issue 9 es_ES
dc.relation.pasarela S\395262 es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES


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