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Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells

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Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells

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dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Kelly, Daniel John es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Lebourg, Myriam Madeleine es_ES
dc.date.accessioned 2020-04-03T06:03:33Z
dc.date.available 2020-04-03T06:03:33Z
dc.date.issued 2016 es_ES
dc.identifier.uri http://hdl.handle.net/10251/140056
dc.description.abstract [EN] Mechanical cues such as hydrostatic pressure (HP) are known to regulate mesenchymal stem cell (MSC) differentiation. The fate of such cells is also strongly influenced by their substrate. The objective of this study was to test how different modifications of polycaprolactone (PCL) scaffolds would influence the response of MSCs to HP. Porcine bone marrow derived MSCs were cultured on PCL, PCL-hyaluronic acid (HA) and PCL-Bioglass (R) (BG) scaffolds for 35 d and stimulated with aHP bioreactor (10 MPa; 1 Hz; 2 h d(-1)). Scaffold composition was found to modulate the response to HP. MSCs seeded onto both PCL and BGscaffolds responded positively to the application of HP, with increases in cartilage extracellular matrix synthesis and a reduction in type I collagen accumulation. This positive effect was not observed onHAscaffolds. The results of this study demonstrate that changes to scaffold composition can have a notable effect on the response of MSCs to bioreactor culture conditions. es_ES
dc.description.sponsorship Joaquin Rodenas-Rochina acknowledges funding of his PhD and his stay at the Trinity Centre for Bioengineering by the Generalitat Valenciana through ACIF grant (ACIF/2010/238) and BEFPI grant (BEFPI/2012/084) respectively. Funding to Daniel Kelly was provided by Science Foundation Ireland (President of Ireland Young Researcher Award: 08/YI5/B1336) and the European Research Council (StemRepair-Project number 258463) Jose L Gomez Ribelles acknowledges the support of the Ministerio de Economia y Competitividad, MINECO, through the MAT2013-46467-C4-1-R project. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. es_ES
dc.language Inglés es_ES
dc.publisher IOP Publishing es_ES
dc.relation ISCIII/CIBER-BBN es_ES
dc.relation GV/BEFPI/2012/084 es_ES
dc.relation SFI/08/YI5/B1336 es_ES
dc.relation ERC/258463 es_ES
dc.relation GENERALITAT VALENCIANA/ACIF/2010/238 es_ES
dc.relation MINECO/MAT2013-46467-C4-1-R es_ES
dc.relation.ispartof Biomedical Physics & Engineering Express es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mesenchymal stem cells es_ES
dc.subject Scaffold es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.title Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1088/2057-1976/2/3/035005 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/258463/EU es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Ródenas Rochina, J.; Kelly, DJ.; Gómez Ribelles, JL.; Lebourg, MM. (2016). Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells. Biomedical Physics & Engineering Express. 2(3). https://doi.org/10.1088/2057-1976/2/3/035005 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1088/2057-1976/2/3/035005 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 2 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 2057-1976 es_ES
dc.relation.pasarela S\320450 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Research Council es_ES
dc.contributor.funder Science Foundation Ireland es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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