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dc.contributor.author | Ródenas Rochina, Joaquín | es_ES |
dc.contributor.author | Kelly, Daniel John | es_ES |
dc.contributor.author | Gómez Ribelles, José Luís | es_ES |
dc.contributor.author | Lebourg, Myriam Madeleine | es_ES |
dc.date.accessioned | 2020-04-03T06:03:33Z | |
dc.date.available | 2020-04-03T06:03:33Z | |
dc.date.issued | 2016 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/140056 | |
dc.description.abstract | [EN] Mechanical cues such as hydrostatic pressure (HP) are known to regulate mesenchymal stem cell (MSC) differentiation. The fate of such cells is also strongly influenced by their substrate. The objective of this study was to test how different modifications of polycaprolactone (PCL) scaffolds would influence the response of MSCs to HP. Porcine bone marrow derived MSCs were cultured on PCL, PCL-hyaluronic acid (HA) and PCL-Bioglass (R) (BG) scaffolds for 35 d and stimulated with aHP bioreactor (10 MPa; 1 Hz; 2 h d(-1)). Scaffold composition was found to modulate the response to HP. MSCs seeded onto both PCL and BGscaffolds responded positively to the application of HP, with increases in cartilage extracellular matrix synthesis and a reduction in type I collagen accumulation. This positive effect was not observed onHAscaffolds. The results of this study demonstrate that changes to scaffold composition can have a notable effect on the response of MSCs to bioreactor culture conditions. | es_ES |
dc.description.sponsorship | Joaquin Rodenas-Rochina acknowledges funding of his PhD and his stay at the Trinity Centre for Bioengineering by the Generalitat Valenciana through ACIF grant (ACIF/2010/238) and BEFPI grant (BEFPI/2012/084) respectively. Funding to Daniel Kelly was provided by Science Foundation Ireland (President of Ireland Young Researcher Award: 08/YI5/B1336) and the European Research Council (StemRepair-Project number 258463) Jose L Gomez Ribelles acknowledges the support of the Ministerio de Economia y Competitividad, MINECO, through the MAT2013-46467-C4-1-R project. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | IOP Publishing | es_ES |
dc.relation.ispartof | Biomedical Physics & Engineering Express | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Mesenchymal stem cells | es_ES |
dc.subject | Scaffold | es_ES |
dc.subject | Tissue engineering | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.subject.classification | INGENIERIA QUIMICA | es_ES |
dc.title | Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1088/2057-1976/2/3/035005 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/258463/EU/Novel mesenchymal stem cell based therapies for articular cartilage repair/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//BEFPI%2F2012%2F084/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACIF%2F2010%2F238/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/SFI/SFI President of Ireland Young Resercher Award (PIYRA)/08%2FYI5%2FB1336/IE/Mechanobiology of mesenchymal stem cells for articular cartilage repair/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.description.bibliographicCitation | Ródenas Rochina, J.; Kelly, DJ.; Gómez Ribelles, JL.; Lebourg, MM. (2016). Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells. Biomedical Physics & Engineering Express. 2(3). https://doi.org/10.1088/2057-1976/2/3/035005 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1088/2057-1976/2/3/035005 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 2 | es_ES |
dc.description.issue | 3 | es_ES |
dc.identifier.eissn | 2057-1976 | es_ES |
dc.relation.pasarela | S\320450 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Science Foundation Ireland | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina | es_ES |
dc.contributor.funder | European Commission | |
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