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Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin Demonstrated by Photophysical and Proteomic Techniques

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Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin Demonstrated by Photophysical and Proteomic Techniques

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Nuin Pla, NE.; Pérez-Sala, D.; Lhiaubet-Vallet, VL.; Andreu Ros, MI.; Miranda Alonso, MÁ. (2016). Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin Demonstrated by Photophysical and Proteomic Techniques. Frontiers in Pharmacology. 7(277). https://doi.org/10.3389/fphar.2016.00277

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/140913

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Title: Photosensitivity to Triflusal: Formation of a Photoadduct with Ubiquitin Demonstrated by Photophysical and Proteomic Techniques
Author: Nuin Pla, Neus Edurne Pérez-Sala, Dolores Lhiaubet-Vallet, Virginie Lyria Andreu Ros, María Inmaculada Miranda Alonso, Miguel Ángel
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
[EN] Triflusal is a platelet aggregation inhibitor chemically related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug. Actually, after oral ...[+]
Subjects: Ovalent binding to protein , Fluorescence , Laser flash photolysis , Lysine , Mass spectrometry , Metabolite , Photoallergy
Copyrigths: Reconocimiento (by)
Source:
Frontiers in Pharmacology. (eissn: 1663-9812 )
DOI: 10.3389/fphar.2016.00277
Publisher:
Frontiers Media SA
Publisher version: https://doi.org/10.3389/fphar.2016.00277
Project ID:
MINECO/CTQ2015-70164-P
...[+]
MINECO/CTQ2015-70164-P
ISCIII/CP11/00154
GV/Prometeo
MINECO/SAF2012-36519
ISCIII/RD12/0013/0009
ISCIII/RD12/0013/0008
[-]
Thanks:
Financial support from the Generalitat Valenciana (Prometeo Program), the Spanish Government (MINECO CTQ2015-70164-P to VL-V and SAF2012-36519 to DP-S) and the Carlos III Institute of Health (Grant RIRAAF, RETICS program, ...[+]
Type: Artículo

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