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Bioactive Multilayer Polylactide Films with Controlled Release Capacity of Gallic Acid Accomplished by Incorporating Electrospun Nanostructured Coatings and Interlayers

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Bioactive Multilayer Polylactide Films with Controlled Release Capacity of Gallic Acid Accomplished by Incorporating Electrospun Nanostructured Coatings and Interlayers

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dc.contributor.author Quiles-Carrillo, Luis es_ES
dc.contributor.author Montanes, Nestor es_ES
dc.contributor.author Lagaron, Jose M. es_ES
dc.contributor.author Balart, Rafael es_ES
dc.contributor.author Torres-Giner, Sergio es_ES
dc.date.accessioned 2020-04-17T12:51:10Z
dc.date.available 2020-04-17T12:51:10Z
dc.date.issued 2019-02-01 es_ES
dc.identifier.uri http://hdl.handle.net/10251/140942
dc.description.abstract [EN] The present research reports on the development of bi- and multilayer polylactide (PLA) films by the incorporation of electrospun nanostructured PLA coatings and interlayers containing the antioxidant gallic acid (GA) at 40 wt% onto cast-extruded PLA films. To achieve the bilayer structures, submicron GA-loaded PLA fibers were applied on 200-µm cast PLA films in the form of coatings by electrospinning for 1, 2, and 3 h. For the multilayers, the cast PLA films were first coated on one side by electrospinning, then sandwiched with 10-µm PLA film on the other side, and the resultant whole structure was finally thermally post-treated at 150 ºC without pressure. Whereas the bilayer PLA films easily delaminated and lacked transparency, the multilayers showed sufficient adhesion between layers and high transparency for deposition times during electrospinning of up to 2 h. The incorporation of GA positively contributed to delaying the thermal degradation of PLA for approximately 10 ºC, as all films were thermally stable up to 345 ºC. The in vitro release studies performed in saline medium indicated that the GA released from the bilayer PLA films rapidly increased during the first 5 h of immersion while it stabilized after 45¿250 h. Interestingly, the PLA multilayers offered a high sustained release of GA, having the capacity to deliver the bioactive for over 1000 h. In addition, in the whole tested period, the GA released from the PLA films retained most of its antioxidant functionality. Thus, during the first days, the bilayer PLA films can perform as potent vehicles to deliver GA while the multilayer PLA films are able to show a sustained release of the natural antioxidant for extended periods es_ES
dc.description.sponsorship This research was supported by the Ministry of Science, Innovation, and Universities (MICIU) program numbers MAT2017-84909-C2-2-R and AGL2015-63855-C2-1-R and by the EU H2020 project YPACK (reference number 773872). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation MICINN/AGL2015-63855-C2-1-R es_ES
dc.relation EC/773872 es_ES
dc.relation MICINN/IJCI-2016-29675 es_ES
dc.relation GENERALITAT VALENCIANA/ACIF/2016/182 es_ES
dc.relation MECYD/FPU15/03812 es_ES
dc.relation info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-84909-C2-2-R/ES/PROCESADO Y OPTIMIZACION DE MATERIALES AVANZADOS DERIVADOS DE ESTRUCTURAS PROTEICAS Y COMPONENTES LIGNOCELULOSICOS/ es_ES
dc.relation.ispartof Applied Sciences es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject PLA es_ES
dc.subject GA es_ES
dc.subject Electrospinning es_ES
dc.subject Multilayer films es_ES
dc.subject Bioactive packaging es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Bioactive Multilayer Polylactide Films with Controlled Release Capacity of Gallic Acid Accomplished by Incorporating Electrospun Nanostructured Coatings and Interlayers es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/app9030533 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/773872/EU/HIGH PERFORMANCE POLYHYDROXYALKANOATES BASED PACKAGING TO MINIMISE FOOD WASTE/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Tecnología de Materiales - Institut de Tecnologia de Materials es_ES
dc.description.bibliographicCitation Quiles-Carrillo, L.; Montanes, N.; Lagaron, JM.; Balart, R.; Torres-Giner, S. (2019). Bioactive Multilayer Polylactide Films with Controlled Release Capacity of Gallic Acid Accomplished by Incorporating Electrospun Nanostructured Coatings and Interlayers. Applied Sciences. 9(3):1-17. https://doi.org/10.3390/app9030533 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/app9030533 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 17 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 2076-3417 es_ES
dc.relation.pasarela S\377453 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES


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