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Modelado matemático de ingestas de alimento e infusión de insulina en un paciente con diabetes tipo 1 en lazo cerrado

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Modelado matemático de ingestas de alimento e infusión de insulina en un paciente con diabetes tipo 1 en lazo cerrado

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dc.contributor.author Manrique-Córdoba, J. es_ES
dc.contributor.author Romero-Ante, J. D. es_ES
dc.contributor.author Vivas, A. es_ES
dc.contributor.author Vicente, J.M. es_ES
dc.contributor.author Sabater-Navarro, J. M. es_ES
dc.date.accessioned 2020-05-12T18:11:01Z
dc.date.available 2020-05-12T18:11:01Z
dc.date.issued 2020-04-07
dc.identifier.issn 1697-7912
dc.identifier.uri http://hdl.handle.net/10251/142982
dc.description.abstract [EN] Diabetes mellitus type 1 is a condition in which the pancreas loses its ability to produce enough insulin, increasing the levels of blood glucose. This work presents the design of a mathematical model of the glucose - insulin dynamics of a type 1 diabetes patient, contemplating the contribution to the concentration of blood glucose by the intake of carbohydrates, fats and proteins. The model also includes the absorption dynamics of 5 insulin types, different administration methods of exogenous insulin, and the variation of insulin sensitivity during the day. The model was integrated into a closed-loop insulin regulation algorithm, in order to evaluate the performance of the model and the efficiency of closed-loop treatments, compared to open-loop therapies. The results show the response of the model to different situations of a real patient, and tests of the controller’s performance. es_ES
dc.description.abstract [ES] La diabetes tipo 1 es una afección en la cual el páncreas pierde su capacidad de producir suficiente insulina, incrementando significativamente la concentración de glucosa en la sangre. En el presente trabajo se presenta el diseño de un modelo matemático de las dinámicas glucosa-insulina de un paciente con diabetes tipo 1, el cual contempla el aporte a la concentración de glucosa en la sangre por parte de la ingesta de carbohidratos, grasas y proteínas. El modelo incluye las dinámicas de absorción de 5 tipos de insulina, diferentes métodos de administración de la misma, y la variación de la sensibilidad a la insulina durante el día. Se integró el modelo a un algoritmo de regulación de insulina en lazo cerrado, con el fin de evaluar el desempeño del modelo y la eficacia de los tratamientos en lazo cerrado, en comparación con las terapias en lazo abierto. Los resultados muestran la respuesta del modelo ante distintas situaciones de un paciente real, y pruebas de funcionamiento del controlador. es_ES
dc.language Español es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.relation.ispartof Revista Iberoamericana de Automática e Informática industrial es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Type 1 Diabetes es_ES
dc.subject Mathematical Model Dynamic Glucose Insulin es_ES
dc.subject Insulin Regulation in Closed Loop es_ES
dc.subject Diabetes Tipo 1 es_ES
dc.subject Modelo Matemático Dinámica Glucosa - Insulina es_ES
dc.subject Regulación de Insulina en Lazo Cerrado es_ES
dc.title Modelado matemático de ingestas de alimento e infusión de insulina en un paciente con diabetes tipo 1 en lazo cerrado es_ES
dc.title.alternative Mathematical modeling of food intake and insulin infusion in a patient with type 1 Ddabetes in closed loop es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.4995/riai.2019.11161
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Manrique-Córdoba, J.; Romero-Ante, JD.; Vivas, A.; Vicente, J.; Sabater-Navarro, JM. (2020). Modelado matemático de ingestas de alimento e infusión de insulina en un paciente con diabetes tipo 1 en lazo cerrado. Revista Iberoamericana de Automática e Informática industrial. 17(2):156-168. https://doi.org/10.4995/riai.2019.11161 es_ES
dc.description.accrualMethod OJS es_ES
dc.relation.publisherversion https://doi.org/10.4995/riai.2019.11161 es_ES
dc.description.upvformatpinicio 156 es_ES
dc.description.upvformatpfin 168 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 17 es_ES
dc.description.issue 2 es_ES
dc.identifier.eissn 1697-7920
dc.relation.pasarela OJS\11161 es_ES
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