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Mesoporous Bioactive Glasses Equipped with Stimuli-Responsive Molecular Gates for Controlled Delivery of Levofloxacin against Bacteria

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Mesoporous Bioactive Glasses Equipped with Stimuli-Responsive Molecular Gates for Controlled Delivery of Levofloxacin against Bacteria

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dc.contributor.author Polo, Lorena es_ES
dc.contributor.author Gómez-Cerezo, N. es_ES
dc.contributor.author García-Fernández, Alba es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Vivancos, José-Luis es_ES
dc.contributor.author Arcos, Daniel es_ES
dc.contributor.author Vallet, María es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2020-05-14T03:04:38Z
dc.date.available 2020-05-14T03:04:38Z
dc.date.issued 2018-12 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/143130
dc.description.abstract [EN] An increase of bone diseases incidence has boosted the study of ceramic biomaterials as potential osteo-inductive scaffolds. In particular, mesoporous bioactive glasses have demonstrated to possess a broad application in the bone regeneration field, due their osteo-regenerative capability and their ability to release drugs from the mesoporous structure. These special features have been studied as an option to fight against bone infection, which is one of the most common problems regarding bone regeneration therapies. In this work, a mesoporous bioglass functionalized with polyamines and capped with adenosine triphosphate (ATP) as the molecular gate was developed for the controlled release of the antibiotic levofloxacin. Phosphate bonds of ATP were hydrolyzed in the presence of acid phosphatase (APase), the concentration of which is significantly increased in bone infection due to the activation of bone resorption processes. The solid was characterized and tested successfully against bacteria. The final gated solid induced bacterial death only in the presence of acid phosphatase. Additionally, it was demonstrated that the solid is not toxic against human cells. The double function of the prepared material as a drug delivery system and bone regeneration enhancer confirms the possible development of a new approach in the tissue engineering field, in which controlled release of therapeutic agents can be finely tuned and, at the same time, osteoinduction is favored. es_ES
dc.description.sponsorship The authors thank the Spanish Government for projects MAT2015-64139-C04-01-R, MAT2015-64831-R and MAT2016-75611-R (AEI/FEDER, UE). Generalitat Valenciana (project PROMETEOII/2014/047) and CIBER-BBN (project SPRING) are also acknowledged for their support. M.V.R. acknowledges funding from the European Research Council (Advanced Grant VERDI; ERC-2015-AdG Proposal 694160). L.P. thanks Universitat Politecnica de Valencia for her FPI grant. N.G.C. and A.G. thank to Ministerio de Ciencia e Innovacion and Ministerio de Educacion, Cultura y Deporte for their predoctoral fellowships. The authors also thank the Electron Microscopy Service at the UPV for their support. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bioactive glasses es_ES
dc.subject Controlled release es_ES
dc.subject Drug delivery es_ES
dc.subject Mesoporous materials es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification PROYECTOS DE INGENIERIA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Mesoporous Bioactive Glasses Equipped with Stimuli-Responsive Molecular Gates for Controlled Delivery of Levofloxacin against Bacteria es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201803301 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/694160/EU/polyValent mEsopoRous nanosystem for bone DIseases/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-75611-R/ES/NANOMATERIALES REGENERATIVOS EN ESCENARIOS DE PATOLOGIA OSEA: OSTEOPOROSIS E INFECCION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64831-R/ES/NANOSISTEMA POLIVALENTE CAPAZ DE APORTAR SOLUCIONES PARA HUESO INFECTADO, CON CANCER Y OSTEOPOROTICO./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Proyectos de Ingeniería - Departament de Projectes d'Enginyeria es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Polo, L.; Gómez-Cerezo, N.; García-Fernández, A.; Aznar, E.; Vivancos, J.; Arcos, D.; Vallet, M.... (2018). Mesoporous Bioactive Glasses Equipped with Stimuli-Responsive Molecular Gates for Controlled Delivery of Levofloxacin against Bacteria. Chemistry - A European Journal. 24(71):18944-18951. https://doi.org/10.1002/chem.201803301 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201803301 es_ES
dc.description.upvformatpinicio 18944 es_ES
dc.description.upvformatpfin 18951 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 71 es_ES
dc.identifier.pmid 30203561 es_ES
dc.relation.pasarela S\374964 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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