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A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones

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A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones

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dc.contributor.author Rostoll-Berenguer, J. es_ES
dc.contributor.author Blay, G. es_ES
dc.contributor.author Muñoz Roca, María Del Carmen es_ES
dc.contributor.author Pedro, J.R. es_ES
dc.contributor.author Vila, C. es_ES
dc.date.accessioned 2020-06-02T05:37:41Z
dc.date.available 2020-06-02T05:37:41Z
dc.date.issued 2019-08-02 es_ES
dc.identifier.issn 1523-7060 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144829
dc.description.abstract [EN] An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction conditions using simple and cheap catalysts (Eosin Y and (S)-Proline) for the synthesis of chiral quinoxaline derivatives with good to high yields (up to 94%) and excellent enantioselectivities (up to 99% ee). es_ES
dc.description.sponsorship Financial support from the Agencia Estatal de Investigation (AEI, Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. J.R.-B. thanks the Ministerio de Ciencia, Innovacion y Universidades for an FPU predoctoral contract, and C.V. thanks the Agencia Estatal de Investigacion (AEI, Spanish Government) for an RyC contract (RYC-2016-20187). es_ES
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Organic Letters es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Photoredox catalysis es_ES
dc.subject Tertiary-Amines es_ES
dc.subject Acid es_ES
dc.subject Functionalization es_ES
dc.subject Efficient es_ES
dc.subject Hydrogenation es_ES
dc.subject Methodology es_ES
dc.subject Activation es_ES
dc.subject Alkylation es_ES
dc.subject Complexes es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1021/acs.orglett.9b02157 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84900-P/ES/REACCIONES DE ADICION ENANTIOSELECTIVAS MEDIANTE SISTEMAS MULTICATALITICOS. HERRAMIENTAS PARA LA SINTESIS EFICIENTE DE MOLECULAS CON ACTIVIDAD FARMACOLOGICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//RYC-2016-20187/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Rostoll-Berenguer, J.; Blay, G.; Muñoz Roca, MDC.; Pedro, J.; Vila, C. (2019). A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones. Organic Letters. 21(15):6011-6015. https://doi.org/10.1021/acs.orglett.9b02157 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1021/acs.orglett.9b02157 es_ES
dc.description.upvformatpinicio 6011 es_ES
dc.description.upvformatpfin 6015 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 15 es_ES
dc.relation.pasarela S\395263 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES


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