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Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization

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Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization

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dc.contributor.author Rico Tortosa, Patricia María es_ES
dc.contributor.author Rodrigo Navarro, Aleixandre es_ES
dc.contributor.author La Peña Del Rivero, Marcos De es_ES
dc.contributor.author Moulisova, Vladimira es_ES
dc.contributor.author Costell, Mercedes es_ES
dc.contributor.author Salmerón Sánchez, Manuel es_ES
dc.date.accessioned 2020-06-13T03:32:50Z
dc.date.available 2020-06-13T03:32:50Z
dc.date.issued 2018-10-30 es_ES
dc.identifier.uri http://hdl.handle.net/10251/146286
dc.description.abstract [EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and show that simultaneous stimulation of NaBC1 and vascular growth factor receptors (VEGFR) promote angiogenesis in vitro and in vivo with ultra-low concentrations of VEGF. We show Human Umbilical Vein Endothelial Cells (HUVEC) organization into tubular structures indicative of vascularization potential. Enhanced cell sprouting was found only in the presence of VEGF and boron, effect abrogated after blocking NaBC1. We demonstrate that stimulated NaBC1 promotes angiogenesis via PI3k-independent pathways and that ¿5ß1/¿vß3-integrin binding is not essential to enhanced HUVEC organization. We describe a novel vascularization mechanism that involves the crosstalk and colocalization between NaBC1/VEGFR receptors. This has important translational consequences: just by administering boron, taking advantage of endogenous VEGF, in vivo vascularization is shown in a chorioallantoic membrane assay. es_ES
dc.description.sponsorship P.R. acknowledges support from the Ministerio de Economia, Industria y Competitividad, Gobierno de Espana (MINECO) (MAT2015-69315-C3-1-R), and European Regional Development Fund (FEDER). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. M. S. S. acknowledges support from the European Research Council (ERC-HealInSynergy 306990) and the UK Engineering and Physical Sciences Research Council (EPSRC-EP/P001114/1). The authors are very grateful to Productos Florida farm for kindly providing chick embryos for CAM assay. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Advanced Biosystems es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject NaBC1 es_ES
dc.subject Boron ion es_ES
dc.subject VEGF es_ES
dc.subject Vascularization es_ES
dc.subject Fibronectin es_ES
dc.subject Integrins es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/adbi.201800220 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/306990/EU/Material-driven Fibronectin Fibrillogenesis to Engineer Synergistic Growth Factor Microenvironments/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UKRI//EP%2FP001114%2F1/GB/Engineering growth factor microenvironments - a new therapeutic paradigm for regenerative medicine/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-69315-C3-1-R/ES/SOPORTES CELULARES BIODEGRADABLES CARGADOS CON IONES BIOACTIVOS PARA REGENERACION MUSCULAR/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Rico Tortosa, PM.; Rodrigo Navarro, A.; La Peña Del Rivero, MD.; Moulisova, V.; Costell, M.; Salmerón Sánchez, M. (2018). Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization. Advanced Biosystems. 3(1):1-12. https://doi.org/10.1002/adbi.201800220 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/adbi.201800220 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 3 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2366-7478 es_ES
dc.relation.pasarela S\379964 es_ES
dc.contributor.funder UK Research and Innovation es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Engineering and Physical Sciences Research Council, Reino Unido es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
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