Rocamonde, B.; Paradells, S.; Garcia Esparza, MA.; Sanchez Vives, M.; Sauro, S.; Martínez-Ramos, C.; Monleón Pradas, M.... (2016). Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury. Brain Injury. 30(2):208-216. https://doi.org/10.3109/02699052.2015.1091505
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/146884
Title:
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Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury
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Author:
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Rocamonde, Brenda
Paradells, Sara
Garcia Esparza, M. Angeles
Sanchez Vives, Mavi
Sauro, Salvatore
Martínez-Ramos, Cristina
Monleón Pradas, Manuel
Soria, Jose Miguel
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UPV Unit:
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Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
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Issued date:
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Abstract:
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[EN] Primary objective: The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid.
Research design: Histological, cytological ...[+]
[EN] Primary objective: The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid.
Research design: Histological, cytological and structural analysis of a combined treatment after a brain cryo-injury model in rats.
Methods and procedures: Adult Wistar rats were subjected to cryogenic brain injury. A channelled-porous scaffold of ethyl acrylate and hydroxyethylacrylate, p(EA-co-HEA) was grafted into cerebral penumbra alone or combined with intraperitoneal LA administration. Histological and cytological evaluation was performed after 15 and 60 days and structural magnetic resonance (MRI) assessment was performed at 2 and 6 months after the surgery.
Main outcomes and results: The scaffold was suitable for the establishment of different cellular types. The results obtained suggest that this strategy promotes blood vessels formation, decreased microglial response and neuron migration, particularly when LA was administrated.
Conclusions: These evidences demonstrated that the combination of a channelled polymer scaffold with LA administration may represent a potential treatment for neural tissue repair after brain injury.
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Subjects:
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Brain injury
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Biopolymers
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Lipoic acid
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Oxidative stress
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Neural repairing
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Brain Injury. (issn:
0269-9052
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DOI:
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10.3109/02699052.2015.1091505
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Publisher:
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Taylor & Francis
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Publisher version:
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http://dx.doi.org/10.3109/02699052.2015.1091505
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Project ID:
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Universidad CEU Cardenal Herrera/PRCEU-UCH 34/12
Universidad CEU Cardenal Herrera/PRCEU-UCH 38/10
MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /PRI-PIMNEU-2011-1372
MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /MAT2011-28791-C03-02
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Thanks:
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The authors report no conflicts of interest. JMSL acknowledges
funding through Programa de Ayudas a la Investigación
Científica Universidad CEU-Cardenal Herrera (PRCEU-UCH
34/12), PRCEU-UCH 38/10 and programa ayudas a ...[+]
The authors report no conflicts of interest. JMSL acknowledges
funding through Programa de Ayudas a la Investigación
Científica Universidad CEU-Cardenal Herrera (PRCEU-UCH
34/12), PRCEU-UCH 38/10 and programa ayudas a grupos
consolidados 2014-15). CMR and MMP acknowledge financing
through projects MAT2011-28791-C03-02 and ERA-NET
NEURON project PRI-PIMNEU-2011-1372.
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Type:
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Artículo
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