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Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury

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Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury

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dc.contributor.author Rocamonde, Brenda es_ES
dc.contributor.author Paradells, Sara es_ES
dc.contributor.author Garcia Esparza, M. Angeles es_ES
dc.contributor.author Sanchez Vives, Mavi es_ES
dc.contributor.author Sauro, Salvatore es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Soria, Jose Miguel es_ES
dc.date.accessioned 2020-06-24T03:31:44Z
dc.date.available 2020-06-24T03:31:44Z
dc.date.issued 2016 es_ES
dc.identifier.issn 0269-9052 es_ES
dc.identifier.uri http://hdl.handle.net/10251/146884
dc.description.abstract [EN] Primary objective: The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid. Research design: Histological, cytological and structural analysis of a combined treatment after a brain cryo-injury model in rats. Methods and procedures: Adult Wistar rats were subjected to cryogenic brain injury. A channelled-porous scaffold of ethyl acrylate and hydroxyethylacrylate, p(EA-co-HEA) was grafted into cerebral penumbra alone or combined with intraperitoneal LA administration. Histological and cytological evaluation was performed after 15 and 60 days and structural magnetic resonance (MRI) assessment was performed at 2 and 6 months after the surgery. Main outcomes and results: The scaffold was suitable for the establishment of different cellular types. The results obtained suggest that this strategy promotes blood vessels formation, decreased microglial response and neuron migration, particularly when LA was administrated. Conclusions: These evidences demonstrated that the combination of a channelled polymer scaffold with LA administration may represent a potential treatment for neural tissue repair after brain injury. es_ES
dc.description.sponsorship The authors report no conflicts of interest. JMSL acknowledges funding through Programa de Ayudas a la Investigación Científica Universidad CEU-Cardenal Herrera (PRCEU-UCH 34/12), PRCEU-UCH 38/10 and programa ayudas a grupos consolidados 2014-15). CMR and MMP acknowledge financing through projects MAT2011-28791-C03-02 and ERA-NET NEURON project PRI-PIMNEU-2011-1372. es_ES
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation.ispartof Brain Injury es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Brain injury es_ES
dc.subject Biopolymers es_ES
dc.subject Lipoic acid es_ES
dc.subject Oxidative stress es_ES
dc.subject Neural repairing es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3109/02699052.2015.1091505 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Universidad CEU Cardenal Herrera//PRCEU-UCH 34%2F12/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Universidad CEU Cardenal Herrera//PRCEU-UCH 38%2F10/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PRI-PIMNEU-2011-1372/ES/MATERIALES BIFUNCIONALES PARA LA REGENERACION NEURAL DE AREAS AFECTADAS POR ICTUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-02/ES/MATERIALES DE SOPORTE Y LIBERACION CONTROLADA PARA LA REGENERACION DE ESTRUCTURAS NEURALES AFECTADAS POR ICTUS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Rocamonde, B.; Paradells, S.; Garcia Esparza, MA.; Sanchez Vives, M.; Sauro, S.; Martínez-Ramos, C.; Monleón Pradas, M.... (2016). Combined application of polyacrylate scaffold and lipoic acid treatment promotes neural tissue reparation after brain injury. Brain Injury. 30(2):208-216. https://doi.org/10.3109/02699052.2015.1091505 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3109/02699052.2015.1091505 es_ES
dc.description.upvformatpinicio 208 es_ES
dc.description.upvformatpfin 216 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 30 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\334705 es_ES
dc.contributor.funder Universidad CEU Cardenal Herrera es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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