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dc.contributor.author | Martinez-Pardo, Pablo | es_ES |
dc.contributor.author | Blay, Gonzalo | es_ES |
dc.contributor.author | Vila, Carlos | es_ES |
dc.contributor.author | Sanz-Marco, Amparo | es_ES |
dc.contributor.author | Muñoz Roca, María Del Carmen | es_ES |
dc.contributor.author | Pedro, Jose R. | es_ES |
dc.date.accessioned | 2020-07-10T03:31:32Z | |
dc.date.available | 2020-07-10T03:31:32Z | |
dc.date.issued | 2019 | es_ES |
dc.identifier.issn | 0022-3263 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/147736 | |
dc.description.abstract | [EN] The first enantioselective formal [3 + 2] cycloaddition between ¿-isocyanoesters and trifluoromethylketones to give 5-trifluoromethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a quaternary stereocenter substituted with a CF3 group, has been developed. The reaction is based upon a multicatalytic approach that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as Lewis acid. The reaction could be achieved with a range of aryl and heteroaryl trifluoromethyl ketones, and the resulting oxazolines were obtained with good to excellent diastereo- and enantioselectivity. | es_ES |
dc.description.sponsorship | Financial support from the MINECO and FEDER (CTQ2017-84900-P). Access to NMR and MS facilities from SCSIE-UV. C.V. thanks the Spanish Government for a Ramon y Cajal contract (RyC-2016-20187). A.S.-M. thanks the Generalitat Valenciana and Fondo Social Europeo for a postdoctoral grant (APOST/2016/139). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | The Journal of Organic Chemistry | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Enantioselective Synthesis of 5-Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/acs.joc.8b02808 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84900-P/ES/REACCIONES DE ADICION ENANTIOSELECTIVAS MEDIANTE SISTEMAS MULTICATALITICOS. HERRAMIENTAS PARA LA SINTESIS EFICIENTE DE MOLECULAS CON ACTIVIDAD FARMACOLOGICA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RYC-2016-20187/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//APOSTD%2F2016%2F139/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada | es_ES |
dc.description.bibliographicCitation | Martinez-Pardo, P.; Blay, G.; Vila, C.; Sanz-Marco, A.; Muñoz Roca, MDC.; Pedro, JR. (2019). Enantioselective Synthesis of 5-Trifluoromethyl-2-oxazolines under Dual Silver/Organocatalysis. The Journal of Organic Chemistry. 84(1):314-325. https://doi.org/10.1021/acs.joc.8b02808 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acs.joc.8b02808 | es_ES |
dc.description.upvformatpinicio | 314 | es_ES |
dc.description.upvformatpfin | 325 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 84 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.pmid | 30537821 | es_ES |
dc.identifier.pmcid | 04-01-2019 | es_ES |
dc.relation.pasarela | S\392181 | es_ES |
dc.contributor.funder | European Social Fund | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |