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Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cells

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Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cells

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dc.contributor.author Ressler, Antonia es_ES
dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.contributor.author Rogina, Anamarija es_ES
dc.contributor.author Ferrer, G.G. es_ES
dc.date.accessioned 2020-07-15T03:32:50Z
dc.date.available 2020-07-15T03:32:50Z
dc.date.issued 2018-10-01 es_ES
dc.identifier.issn 0144-8617 es_ES
dc.identifier.uri http://hdl.handle.net/10251/148015
dc.description.abstract [EN] Injectable hydrogels have emerged as promising biomaterials for tissue engineering applications. The goal of this study was to evaluate the potential of a pH-responsive chitosan-hydroxyapatite hydrogel to be used as a three-dimensional support for encapsulated mesenchymal stem cells (MSCs) osteogenic differentiation. In vitro enzymatic degradation of the hydrogel, during 28 days of incubation, in simulated physiological condiditons, was characterized by swelling measurements, molecular weight determination and SEM analysis of hydrogel microstructure. Osteogenic differentiation of encapsulated MSCs was confirmed by osteogenic Runx2, collagen type I and osteocalcin immunostaining and alkaline phosphatase quantification. The deposition of late osteogenic markers (calcium phosphates) detected by Alizarin red and von Kossa staining indicated an extracellular matrix mineralization. es_ES
dc.description.sponsorship This work has been supported in part by the Croatian Science Foundation under the project IP-2014-09-3752 by the Spanish Ministry through the MAT2016-76039-C4-1-R project (including the FEDER financial support). Joaquin Rodenas-Rochina acknowledges funding by the Conselleria de Educacion, Investigacion, Cultura y Deporte (Generalitat Valenciana) and co-funding by Fondo Social Europeo (FSE) through APOSTD grant (APOSTD/2016/006). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Carbohydrate Polymers es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Chitosan es_ES
dc.subject Differentiation es_ES
dc.subject Hydrogel es_ES
dc.subject Hydroxyapatite es_ES
dc.subject MSCs es_ES
dc.subject Osteogenesis es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cells es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.carbpol.2018.06.029 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/IP-2014-09-3752/
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2016%2F006/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Ressler, A.; Ródenas Rochina, J.; Ivankovic, M.; Ivankovic, H.; Rogina, A.; Ferrer, G. (2018). Injectable chitosan-hydroxyapatite hydrogels promote the osteogenic differentiation of mesenchymal stem cells. Carbohydrate Polymers. 197:469-477. https://doi.org/10.1016/j.carbpol.2018.06.029 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.carbpol.2018.06.029 es_ES
dc.description.upvformatpinicio 469 es_ES
dc.description.upvformatpfin 477 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 197 es_ES
dc.identifier.pmid 30007636 es_ES
dc.relation.pasarela S\379121 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Croatian Science Foundation es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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