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Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery

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Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery

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dc.contributor.author Oroval, Mar es_ES
dc.contributor.author Díez, Paula es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Coll Merino, Mª Carmen es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Villalonga, R. es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2020-07-22T03:31:36Z
dc.date.available 2020-07-22T03:31:36Z
dc.date.issued 2017-01-26 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/148457
dc.description "This is the peer reviewed version of the following article: Oroval, Mar, Paula Díez, Elena Aznar, Carmen Coll, María Dolores Marcos, Félix Sancenón, Reynaldo Villalonga, and Ramón Martínez-Máñez. 2016. Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery. Chemistry - A European Journal 23 (6). Wiley: 1353 60. doi:10.1002/chem.201604104, which has been published in final form at https://doi.org/10.1002/chem.201604104. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." es_ES
dc.description.abstract [EN] We describe herein the preparation of glucose-sensitive capped mesoporous silica nanoparticles for insulin delivery. The new material consists of an expanded-pore nanometric silica support grafted with 1-propyl-1-H-benzimidazole groups, loaded with fluorescein isothiocyanate-labeled insulin (FITC-Ins) and capped by the formation of inclusion complexes between cyclodextrin-modified glucose oxidase (CD-GOx) and the benzimidazole groups grafted on the mesoporous support. Insulin delivery from the gated material in simulated blood plasma was assessed upon addition of glucose. Glucose is transformed by GOx into gluconic acid, which promoted the dethreading of the benzimidazole-CD-GOx inclusion complexes, allowing cargo release. Small quantities of this support would be needed to release the amount of insulin necessary to decrease diabetic blood glucose concentrations to regular levels. es_ES
dc.description.sponsorship The authors thank the Spanish Government (projects CTQ2011-24355, MAT2015-64139-C4-1-R, CTQ2014-58989-P, and AGL2015-70235-C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. M.O. thanks the Universitat Politecnica de Valencia for her FPI grant. P.D. thanks the Ministerio de Economia y Competitividad for her FPI grant (BES-2012-054066). C.C. thanks the Generalitat Valenciana for her postdoctoral contract VALi+D. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Responsive controlled-release es_ES
dc.subject Molecular-Transport es_ES
dc.subject Triggered release es_ES
dc.subject Concanavalin-A es_ES
dc.subject Folic-Acid es_ES
dc.subject System es_ES
dc.subject Encapsulation es_ES
dc.subject Design es_ES
dc.subject Drugs es_ES
dc.subject Loop es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201604104 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2011-24355/ES/NUEVOS NANOMATERIALES POLIFUNCIONALIZADOS PARA LA CONSTRUCCION DE BIOSENSORES DE DETECCION MULTIPLE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2012-054066/ES/BES-2012-054066/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2014-58989-P/ES/BIONANORROBOTS QUIMICAMENTE PROGRAMADOS Y CONTROLADOS POR ENZIMAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2015-70235-C2-2-R/ES/DESARROLLO DE SISTEMAS HIBRIDOS CON OPTIMIZACION DEL ANCLADO DE BIOMOLECULAS Y DISEÑADOS CON PROPIEDADES DE ENCAPSULACION Y LIBERACION CONTROLADA MEJORADAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Oroval, M.; Díez, P.; Aznar, E.; Coll Merino, MC.; Marcos Martínez, MD.; Sancenón Galarza, F.; Villalonga, R.... (2017). Self-Regulated Glucose-Sensitive Neoglycoenzyme-Capped Mesoporous Silica Nanoparticles for Insulin Delivery. Chemistry - A European Journal. 23(6):1353-1360. https://doi.org/10.1002/chem.201604104 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201604104 es_ES
dc.description.upvformatpinicio 1353 es_ES
dc.description.upvformatpfin 1360 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 23 es_ES
dc.description.issue 6 es_ES
dc.identifier.pmid 27859880 es_ES
dc.relation.pasarela S\326114 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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