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Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications

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Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications

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dc.contributor.author FERNÁNDEZ DÍAZ, ROMÁN es_ES
dc.contributor.author García Molla, Pablo es_ES
dc.contributor.author García, María es_ES
dc.contributor.author García Narbón, José Vicente es_ES
dc.contributor.author Jiménez Jiménez, Yolanda es_ES
dc.contributor.author Arnau Vives, Antonio es_ES
dc.date.accessioned 2020-07-30T03:35:46Z
dc.date.available 2020-07-30T03:35:46Z
dc.date.issued 2017-09-08 es_ES
dc.identifier.uri http://hdl.handle.net/10251/148911
dc.description.abstract [EN] Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators. The sensor is also validated for bio-sensing applications. For this purpose, a specific sensor cell was designed and manufactured that addresses the critical requirements associated with this type of sensor and application. Due to the small sensing area and the sensor's fragility, these requirements include a low-volume flow chamber in the nanoliter range, and a system approach that provides the appropriate pressure control for assuring liquid confinement while maintaining the integrity of the sensor with a good base line stability and easy sensor replacement. The sensor characteristics make it suitable for consideration as the elemental part of a sensor matrix in a multichannel platform for point of care applications. es_ES
dc.description.sponsorship This work was funded by the European Commission Horizon 2020 Programme under Grant Agreement number ICT-28-2015/687785-LIQBIOPSENS (Reliable Liquid Biopsy technology for early detection of colorectal cancer). es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Sensors es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject HFF-QCM(high fundamental frequency quartz crystalmicrobalance) es_ES
dc.subject Finite elementmethod (FEM) es_ES
dc.subject Flow cell,biosensor es_ES
dc.subject PoC (point of care) es_ES
dc.subject MQCM(monolithic quartz crystal microbalance) es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/s17092057 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/687785/EU/Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Fernández Díaz, R.; García Molla, P.; García, M.; García Narbón, JV.; Jiménez Jiménez, Y.; Arnau Vives, A. (2017). Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications. Sensors. 17(9):1-13. https://doi.org/10.3390/s17092057 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/s17092057 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 13 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 17 es_ES
dc.description.issue 9 es_ES
dc.identifier.eissn 1424-8220 es_ES
dc.identifier.pmid 28885551 es_ES
dc.identifier.pmcid PMC5621382 es_ES
dc.relation.pasarela S\355418 es_ES
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