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The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations

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The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations

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dc.contributor.author Mattenberger, Florian es_ES
dc.contributor.author Sabater-Muñoz, B. es_ES
dc.contributor.author Toft, C. es_ES
dc.contributor.author Fares Riaño, Mario Ali es_ES
dc.date.accessioned 2020-09-12T03:34:03Z
dc.date.available 2020-09-12T03:34:03Z
dc.date.issued 2017-01 es_ES
dc.identifier.uri http://hdl.handle.net/10251/149920
dc.description.abstract [EN] Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations . However, here we show that increased phenotypic plasticity after duplication plays a more major role than thought before in the origin of adaptations. We perform an exhaustive analysis of the transcriptional alterations of duplicated genes in the unicellular eukaryote Sac- charomyces cerevisiae when challenged with five different environmental stresses. Analysis of the tran- scriptomes of yeast shows that gene duplication increases the transcriptional response to environmental changes, with duplicated genes exhibiting signatures of adaptive transcriptional patterns in response to stress. The mechanism of duplication matters, with whole-genome duplicates being more transcriptionally altered than small-scale duplicates. The predominant transcriptional pattern follows the classic theory of evolution by gene duplication; with one gene copy remaining unaltered under stress, while its sister copy presents large transcriptional plasticity and a prominent role in adaptation. Moreover, we find additional transcriptional profiles that are suggestive of neo- and subfunctionalization of duplicate gene copies. These patterns are strongly correlated with the functional dependencies and sequence divergence profiles of gene copies. We show that, unlike singletons, duplicates respond more specifically to stress, supporting the role of natural selection in the transcriptional plasticity of duplicates. Our results reveal the underlying transcriptional complexity of duplicated genes and its role in the origin of adaptations. es_ES
dc.description.sponsorship This work was supported by a grant from the Spanish Ministerio de Economia y Competitividad (reference: BFU2015-66073-P) and a grant (reference: ACOMP/2015/026) from the local government Conselleria de Educacion Investigacion, Cultura y Deporte, Generalitat Valenciana to M.A.F. C.T. was supported by a grant Juan de la Cierva from the Spanish Ministerio de Economia y Competitividad (reference: JCA-2012-14056). es_ES
dc.language Inglés es_ES
dc.publisher The Genetics Society of America es_ES
dc.relation.ispartof G3: Genes, Genomes, Genetics (Bethesda) es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Evolutionary biology es_ES
dc.subject Gene function es_ES
dc.subject Small-scale duplicates es_ES
dc.subject Whole-genome duplicates es_ES
dc.subject Transcriptional profiles es_ES
dc.title The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1534/g3.116.035329 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-66073-P/ES/CARACTERIZANDO LOS MECANISMOS DE INNOVACION POR DUPLICACION GENICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2015%2F026/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//JCI-2012-14056/ES/JCI-2012-14056/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Mattenberger, F.; Sabater-Muñoz, B.; Toft, C.; Fares Riaño, MA. (2017). The Phenotypic Plasticity of Duplicated Genes in Saccharomyces cerevisiae and the Origin of Adaptations. G3: Genes, Genomes, Genetics (Bethesda). 7(1):63-75. https://doi.org/10.1534/g3.116.035329 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1534/g3.116.035329 es_ES
dc.description.upvformatpinicio 63 es_ES
dc.description.upvformatpfin 75 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2160-1836 es_ES
dc.identifier.pmid 27799339 es_ES
dc.identifier.pmcid PMC5217124 es_ES
dc.relation.pasarela S\324400 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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