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Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates

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Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates

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Vila, C.; Quintero, L.; Blay, G.; Muñoz Roca, MDC.; Pedro, J. (2016). Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates. Organic Letters. 18(21):5652-5655. https://doi.org/10.1021/acs.orglett.6b02893

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/150297

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Title: Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates
Author: Vila, C. Quintero, L. Blay, G. Muñoz Roca, María Del Carmen Pedro, J.R.
UPV Unit: Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
Issued date:
Abstract:
[EN] An efficient organocatalytic asymmetric synthesis of alpha-hydroxyketones has been developed. Quinine-derived thiourea catalyzed the enantioselective Friedel Crafts alkylation of naphthols and activated phenols with ...[+]
Subjects: Dynamic kinetic resolution , Intramolecular Cannizzaro reaction , Asymmetric benzoin condensation , Electron-Rich phenols , One-Pot synthesis , Highly efficient , Cinchona alkaloids , Carbonyl-Compounds , (R)-Alpha-Hydroxy ketones , Stereoselective-Synthesis
Copyrigths: Cerrado
Source:
Organic Letters. (issn: 1523-7060 )
DOI: 10.1021/acs.orglett.6b02893
Publisher:
American Chemical Society
Publisher version: https://doi.org/10.1021/acs.orglett.6b02893
Thanks:
Financial support from the MINECO (Gobierno de Espana; CTQ2013-47494-P) is gratefully acknowledged. C.V. thanks MINECO for a JdC contract. Access to NMR, MS, and X-ray facilities from the Servei Central de Suport a la ...[+]
Type: Artículo

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