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dc.contributor.author | Vila, C. | es_ES |
dc.contributor.author | Quintero, L. | es_ES |
dc.contributor.author | Blay, G. | es_ES |
dc.contributor.author | Muñoz Roca, María Del Carmen | es_ES |
dc.contributor.author | Pedro, J.R. | es_ES |
dc.date.accessioned | 2020-09-18T03:34:14Z | |
dc.date.available | 2020-09-18T03:34:14Z | |
dc.date.issued | 2016-11-04 | es_ES |
dc.identifier.issn | 1523-7060 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/150297 | |
dc.description.abstract | [EN] An efficient organocatalytic asymmetric synthesis of alpha-hydroxyketones has been developed. Quinine-derived thiourea catalyzed the enantioselective Friedel Crafts alkylation of naphthols and activated phenols with aryl- and alkylglyoxal hydrates, providing the corresponding chiral alpha-hydroxyketones with high yields (up to 97%) and excellent enantioselectivities (up to 99% ee). | es_ES |
dc.description.sponsorship | Financial support from the MINECO (Gobierno de Espana; CTQ2013-47494-P) is gratefully acknowledged. C.V. thanks MINECO for a JdC contract. Access to NMR, MS, and X-ray facilities from the Servei Central de Suport a la Investigacio Experimental (SCSIE)-UV is also acknowledged. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | Organic Letters | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Dynamic kinetic resolution | es_ES |
dc.subject | Intramolecular Cannizzaro reaction | es_ES |
dc.subject | Asymmetric benzoin condensation | es_ES |
dc.subject | Electron-Rich phenols | es_ES |
dc.subject | One-Pot synthesis | es_ES |
dc.subject | Highly efficient | es_ES |
dc.subject | Cinchona alkaloids | es_ES |
dc.subject | Carbonyl-Compounds | es_ES |
dc.subject | (R)-Alpha-Hydroxy ketones | es_ES |
dc.subject | Stereoselective-Synthesis | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/acs.orglett.6b02893 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2013-47494-P/ES/NUEVOS RETOS EN EL DESARROLLO DE PROCESOS ENANTIOSELECTIVOS DE FORMACION DE ENLACES C-C MEDIANTE CATALISIS DUAL COOPERATIVA./ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada | es_ES |
dc.description.bibliographicCitation | Vila, C.; Quintero, L.; Blay, G.; Muñoz Roca, MDC.; Pedro, J. (2016). Organocatalytic Enantioselective Synthesis of alpha-Hydroxyketones through a Friedel-Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates. Organic Letters. 18(21):5652-5655. https://doi.org/10.1021/acs.orglett.6b02893 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acs.orglett.6b02893 | es_ES |
dc.description.upvformatpinicio | 5652 | es_ES |
dc.description.upvformatpfin | 5655 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 18 | es_ES |
dc.description.issue | 21 | es_ES |
dc.identifier.pmid | 27779412 | es_ES |
dc.relation.pasarela | S\325709 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |