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Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

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Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles

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dc.contributor.author De la Torre Paredes, Cristina es_ES
dc.contributor.author Mondragón Martínez, Laura es_ES
dc.contributor.author Coll Merino, Mª Carmen es_ES
dc.contributor.author García-Fernández, Alba es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Amorós, Pedro es_ES
dc.contributor.author Pérez Payá, Enrique es_ES
dc.contributor.author Orzáez, Mar es_ES
dc.date.accessioned 2020-09-18T03:35:26Z
dc.date.available 2020-09-18T03:35:26Z
dc.date.issued 2015-10-26 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150334
dc.description.abstract [EN] Excessive apoptotic cell death is at the origin of several pathologies, such as degenerative disorders, stroke or ischemia-reperfusion damage. In this context, strategies to improve inhibition of apoptosis and other types of cell death are of interest and may represent a pharmacological opportunity for the treatment of cell-death-related disorders. In this scenario new peptide-containing delivery systems (solids S1-P1and S1-P2) are described based on meso-porous silica nanoparticles (MSNs) loaded with a dye and capped with the KKGDEVDKKARDEVDK (P1) peptide that contains two repeats of the DEVD target sequence that are selectively hydrolyzed by caspase3 (C3). This enzyme plays a central role in the execution-phase of apoptosis. HeLa cells electroporated with S1 P1are able to deliver the cargo in the presence of staurosporin (STS), which induces apoptosis with the consequent activation of the cytoplasmic C3 enzyme. Moreover, the nanoparticles S1-P2,containing both a cell-penetrating TAT peptide and P1 also entered in HeLa cells and delivered the cargo preferentially in cells treated with the apoptosis inducer cisplatin. es_ES
dc.description.sponsorship We thank the Spanish Government (Project MAT2012-38429-C04 and SAF2010-15512) and the Generalitat Valenciana (PROMETEOII/2014/061) for support. C.T. is grateful to the Spanish Ministry of Science and Innovation for her PhD fellowship. L.M. thanks the Generalitat Valenciana (VALI+D program), Nice city council ("Aides Individuelles aux Jeunes Chercheurs - 2011") and Fondation de la Recherche Medicale for her postdoctoral contracts. C.C. thanks the Generalitat Valenciana for their postdoctoral contract VALI+D. We thank the confocal microscopy service, Alberto Hernandez from CIPF confocal microscopy service for their technical support. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Caspase 3 es_ES
dc.subject Controlled release es_ES
dc.subject Gated mesoporous materials es_ES
dc.subject Nanoparticles es_ES
dc.subject Peptides es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201502413 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//SAF2010-15512/ES/MECANISMOS MOLECULARES DE MODULADORES DE APOPTOSIS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation De La Torre Paredes, C.; Mondragón Martínez, L.; Coll Merino, MC.; García-Fernández, A.; Sancenón Galarza, F.; Martínez-Máñez, R.; Amorós, P.... (2015). Caspase 3 Targeted Cargo Delivery in Apoptotic Cells Using Capped Mesoporous Silica Nanoparticles. Chemistry - A European Journal. 21(44):15506-15510. https://doi.org/10.1002/chem.201502413 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201502413 es_ES
dc.description.upvformatpinicio 15506 es_ES
dc.description.upvformatpfin 15510 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 44 es_ES
dc.identifier.pmid 26493876 es_ES
dc.relation.pasarela S\299637 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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