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Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942

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Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942

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dc.contributor.author Triana, Julian es_ES
dc.contributor.author Montagud, Arnau es_ES
dc.contributor.author Siurana, Maria es_ES
dc.contributor.author Fuente, David es_ES
dc.contributor.author Urchueguia, Arantxa es_ES
dc.contributor.author Gamermann, Daniel es_ES
dc.contributor.author Torres, Javier es_ES
dc.contributor.author TENA, JOSÉ es_ES
dc.contributor.author Fernández de Córdoba, Pedro es_ES
dc.contributor.author Urchueguía Schölzel, Javier Fermín es_ES
dc.date.accessioned 2020-10-04T03:31:59Z
dc.date.available 2020-10-04T03:31:59Z
dc.date.issued 2014-08-20 es_ES
dc.identifier.uri http://hdl.handle.net/10251/151045
dc.description.abstract [EN] The reconstruction of genome-scale metabolic models and their applications represent a great advantage of systems biology. Through their use as metabolic flux simulation models, production of industrially-interesting metabolites can be predicted. Due to the growing number of studies of metabolic models driven by the increasing genomic sequencing projects, it is important to conceptualize steps of reconstruction and analysis. We have focused our work in the cyanobacterium Synechococcus elongatus PCC7942, for which several analyses and insights are unveiled. A comprehensive approach has been used, which can be of interest to lead the process of manual curation and genome-scale metabolic analysis. The final model, iSyf715 includes 851 reactions and 838 metabolites. A biomass equation, which encompasses elementary building blocks to allow cell growth, is also included. The applicability of the model is finally demonstrated by simulating autotrophic growth conditions of Synechococcus elongatus PCC7942. es_ES
dc.description.sponsorship The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 308518 (CyanoFactory), from the Spanish Ministerio de Educación Cultura y Deporte grant FPU12/05873 through the program FPU and from the UniversitatPolitècnia de València grant Contratos Predoctorales FPI 2013 es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Metabolites es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Genome-scale metabolic network reconstruction es_ES
dc.subject Systems biology es_ES
dc.subject Metabolic pathways es_ES
dc.subject Flux balance analysis es_ES
dc.subject Biological databases es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification TECNOLOGIA DEL MEDIO AMBIENTE es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942 es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/metabo4030680 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308518/EU/Design, construction and demonstration of solar biofuel production using novel (photo)synthetic cell factories/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//FPU12%2F05873/ES/FPU12%2F05873/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Hidráulica y Medio Ambiente - Departament d'Enginyeria Hidràulica i Medi Ambient es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Matemática Pura y Aplicada - Institut Universitari de Matemàtica Pura i Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Triana, J.; Montagud, A.; Siurana, M.; Fuente, D.; Urchueguia, A.; Gamermann, D.; Torres, J.... (2014). Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942. Metabolites. 4(3):680-698. https://doi.org/10.3390/metabo4030680 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/metabo4030680 es_ES
dc.description.upvformatpinicio 680 es_ES
dc.description.upvformatpfin 698 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 4 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 2218-1989 es_ES
dc.identifier.pmid 25141288 es_ES
dc.identifier.pmcid PMC4192687 es_ES
dc.relation.pasarela S\278781 es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
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