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Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles

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Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles

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dc.contributor.author Villalonga, Reynaldo es_ES
dc.contributor.author Díez, Paula es_ES
dc.contributor.author Sánchez, Alfredo es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Pingarrón, J.M. es_ES
dc.date.accessioned 2020-10-07T03:33:28Z
dc.date.available 2020-10-07T03:33:28Z
dc.date.issued 2013-06 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/151278
dc.description.abstract [EN] Novel Janus nanoparticles with Au and mesoporous silica faces on opposite sides were prepared using a Pickering emulsion template with paraffin wax as the oil phase. These anisotropic colloids were employed as integrated sensing-actuating nanomachines for enzyme-controlled stimuli-responsive cargo delivery. As a proof of concept, we demonstrated the successful use of the Janus colloids for controlled delivery of tris(2,2'-bipyridyl) ruthenium(II) chloride from the mesoporous silica face, which was grafted with pH-sensitive gatelike scaffoldings. The release was mediated by the on-demand catalytic decomposition of urea by urease, which was covalently immobilized on the Au face. es_ES
dc.description.sponsorship R. V. acknowledges a Ramon & Cajal contract from the Spanish Ministry of Science and Innovation. Financial support from the Spanish Ministry of Science and Innovation CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, MAT2009-14564-C04-01, MAT2012-38429-C04-01 and Comunidad de Madrid S2009/PPQ-1642, programme AVANSENS, is gratefully acknowledged. The Generalitat Valencia (project PROMETEO/2009/016) is also acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation MINECO/CTQ2011-24355 es_ES
dc.relation MICINN/CTQ2009-12650 es_ES
dc.relation MICINN/CTQ2009-09351 es_ES
dc.relation CAM/S2009/PPQ-1642 es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEO/2009/016 es_ES
dc.relation MINISTERIO DE EDUCACION /MAT2009-14564-C04-01 es_ES
dc.relation MINECO/MAT2012-38429-C04-01 es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Controlled release es_ES
dc.subject Enzyme es_ES
dc.subject Janus nanoparticle es_ES
dc.subject Mesoporous silica es_ES
dc.subject Molecular gates es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201300723 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Villalonga, R.; Díez, P.; Sánchez, A.; Aznar, E.; Martínez-Máñez, R.; Pingarrón, J. (2013). Enzyme-controlled sensing-actuating nanomachine based on Janus Au-mesoporous silica nanoparticles. Chemistry - A European Journal. 19(24):7889-7894. https://doi.org/10.1002/chem.201300723 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201300723 es_ES
dc.description.upvformatpinicio 7889 es_ES
dc.description.upvformatpfin 7894 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 19 es_ES
dc.description.issue 24 es_ES
dc.identifier.pmid 23649789 es_ES
dc.relation.pasarela S\255482 es_ES
dc.contributor.funder Comunidad de Madrid es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder MINISTERIO DE EDUCACION es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD es_ES


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