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Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

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Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

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dc.contributor.author Lee, Peter es_ES
dc.contributor.author Calvo Saiz, Conrado Javier es_ES
dc.contributor.author Alfonso-Almazán, José M. es_ES
dc.contributor.author Quintanilla, Jorge G. es_ES
dc.contributor.author Chorro Gasco, Francisco J. es_ES
dc.contributor.author Yan, Ping es_ES
dc.contributor.author Loew, Leslie M. es_ES
dc.contributor.author Filgueiras-Rama, David es_ES
dc.contributor.author Millet Roig, José es_ES
dc.date.accessioned 2020-10-21T03:31:29Z
dc.date.available 2020-10-21T03:31:29Z
dc.date.issued 2017-02-27 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/152718
dc.description.abstract [EN] Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model. es_ES
dc.description.sponsorship The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). This work was also partially supported by the following sources: Spanish Society of Cardiology (D.F.R.); Jesus Serra Foundation (D.F.R.); Carlos III Health Institute/European Regional Development Fund (ERDF) Grants: CB16/11/00458 (D.F.R., J.G.Q.), FIS PI12/00993 (C.J.C., J.M.), FIS PI15/00748 (C.J.C., J.M.) and FIS PI15/01408 (F.J.C); Generalitat Valenciana Grants GV/2015/019 (C.J.C.) and PROMETEO/2014/037 (C.J.C., F.J.C., J.M.). We thank Daniel Garcia-Leon for his assistance during the Langendorff-perfused heart experiments es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject 3-Dimensional Surface Reconstruction es_ES
dc.subject Persistent Atril-Fibrillation es_ES
dc.subject Tachycardia es_ES
dc.subject.classification INGENIERIA MECANICA es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/srep43217 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F037/ES/ESTUDIO MEDIANTE TÉCNICAS CARTOGRÁFICAS AVANZADAS DE LOS MECANISMOS BÁSICOS IMPLICADOS EN LAS ARRITMIAS MALIGNAS Y EN SU CONTROL/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2015-0505/ES/CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00458/ES/ENFERMEDADES CARDIOVASCULARES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI15%2F01408/ES/Efectos de la inhibición de la desacetilación de las histonas en el remodelado post-infarto del sustrato arritmogénico/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GV%2F2015%2F019/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI12%2F00993/ES/Utilidad de la estabilización de la homeostasis del calcio intracelular en el control de los procesos fibrilatorios/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI15%2F00748/ES/Efectos de la inhibición de la desacetilación de las histonas en el remodelado postinfarto del sustrato arritmogénico/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Lee, P.; Calvo Saiz, CJ.; Alfonso-Almazán, JM.; Quintanilla, JG.; Chorro Gasco, FJ.; Yan, P.; Loew, LM.... (2017). Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models. Scientific Reports. 7:1-14. https://doi.org/10.1038/srep43217 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/srep43217 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.identifier.pmid 28240274 es_ES
dc.identifier.pmcid PMC5327492 es_ES
dc.relation.pasarela S\324272 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
dc.contributor.funder Conselleria d'Educació, Investigació, Cultura i Esport de la Generalitat Valenciana es_ES
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