Rogina, A.; Sandrk, N.; Teruel Biosca, L.; Antunovic, M.; Ivankovic, M.; Gallego Ferrer, G. (2019). Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels. Chemical and Biochemical Engineering Quarterly Journal. 33(3):325-335. https://doi.org/10.15255/CABEQ.2019.1663
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/156665
Title:
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Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
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Author:
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Rogina, A.
Sandrk, N
Teruel Biosca, Laura
Antunovic, M.
Ivankovic, M.
Gallego Ferrer, Gloria
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UPV Unit:
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Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
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Issued date:
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Abstract:
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[EN] Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of ...[+]
[EN] Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydrox yapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells.
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Subjects:
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Gelatine
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Hydroxyapatite
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Injectable
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Hydrogel
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Rheology
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Cytotoxicity
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Chemical and Biochemical Engineering Quarterly Journal. (issn:
0352-9568
)
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DOI:
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10.15255/CABEQ.2019.1663
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Publisher:
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Croatian Society of Chemical Engineers/HDKI
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Publisher version:
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https://doi.org/10.15255/CABEQ.2019.1663
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Project ID:
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HRZZ/IP-2014-09-3752
AEI/MAT2016-76039-C4-1-R
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Thanks:
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The authors are grateful for the financial support of the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R project (including Feder funds) and the Croatian Science Foundation under the project ...[+]
The authors are grateful for the financial support of the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R project (including Feder funds) and the Croatian Science Foundation under the project IP-2014-09-3752.
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Type:
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Artículo
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