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Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels

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Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels

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dc.contributor.author Rogina, A. es_ES
dc.contributor.author Sandrk, N es_ES
dc.contributor.author Teruel Biosca, Laura es_ES
dc.contributor.author Antunovic, M. es_ES
dc.contributor.author Ivankovic, M. es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.date.accessioned 2020-12-10T04:32:12Z
dc.date.available 2020-12-10T04:32:12Z
dc.date.issued 2019 es_ES
dc.identifier.issn 0352-9568 es_ES
dc.identifier.uri http://hdl.handle.net/10251/156665
dc.description.abstract [EN] Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitation of in situ formed hydrox yapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells. es_ES
dc.description.sponsorship The authors are grateful for the financial support of the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R project (including Feder funds) and the Croatian Science Foundation under the project IP-2014-09-3752. es_ES
dc.language Inglés es_ES
dc.publisher Croatian Society of Chemical Engineers/HDKI es_ES
dc.relation.ispartof Chemical and Biochemical Engineering Quarterly Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Gelatine es_ES
dc.subject Hydroxyapatite es_ES
dc.subject Injectable es_ES
dc.subject Hydrogel es_ES
dc.subject Rheology es_ES
dc.subject Cytotoxicity es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.15255/CABEQ.2019.1663 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/HRZZ//IP-2014-09-3752/HR/Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Rogina, A.; Sandrk, N.; Teruel Biosca, L.; Antunovic, M.; Ivankovic, M.; Gallego Ferrer, G. (2019). Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels. Chemical and Biochemical Engineering Quarterly Journal. 33(3):325-335. https://doi.org/10.15255/CABEQ.2019.1663 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.15255/CABEQ.2019.1663 es_ES
dc.description.upvformatpinicio 325 es_ES
dc.description.upvformatpfin 335 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 33 es_ES
dc.description.issue 3 es_ES
dc.relation.pasarela S\410761 es_ES
dc.contributor.funder Croatian Science Foundation es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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