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Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition

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Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition

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Sayas Montañana, EM.; Pérez-Benavente, B.; Manzano, C.; Farràs, R.; Alejandro Martinez, S.; Del Pozo, J.; Ferrando Monleón, AR.... (2019). Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition. FEBS Letters. 593(2):209-218. https://doi.org/10.1002/1873-3468.13299

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Título: Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition
Autor: Sayas Montañana, Enric Miquel Pérez-Benavente, Beatriz Manzano, C. Farràs, Rosa Alejandro Martinez, Santiago del Pozo, J.C. Ferrando Monleón, Alejandro Ramón Serrano Salom, Ramón
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
Fecha difusión:
Resumen:
[EN] Spermidine is a polyamine present in eukaryotes with essential functions in protein synthesis. At high concentrations spermidine and norspermidine inhibit growth by unknown mechanisms. Transcriptomic analysis of the ...[+]
Palabras clave: Amino acid depletion , Arabidopsis , HeLa cells , Ubiquitin ligase , Yeast
Derechos de uso: Cerrado
Fuente:
FEBS Letters. (issn: 0014-5793 )
DOI: 10.1002/1873-3468.13299
Editorial:
John Wiley & Sons
Versión del editor: https://doi.org/10.1002/1873-3468.13299
Código del Proyecto:
info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F041/ES/La homeostasis de cationes monovalentes (H+, K+ y Na+) y el crecimiento y muerte celular/
Agradecimientos:
This work was supported by grant PROMETEO II 2014/041 from Generalitat Valenciana, Valencia, Spain.
Tipo: Artículo

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